非洲爪蟾及其他两栖动物对二甲基亚硝胺（DMN）的消除与代谢
Elimination and metabolism of dimethylnitrosamine (DMN) by Xenopus laevis and other amphibians.
作者信息
Rao R R, Clothier R H, Hodgson R M, Balls M
出版信息
Experientia. 1979 Dec 15;35(12):1661-3. doi: 10.1007/BF01953255.
PMID:520492
Abstract
The elimination of (14C)-DMN after i.p. injection into Xenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver from Xenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism by Xenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic in Xenopus.
摘要
测定了腹腔注射(14C)-二甲基亚硝胺后非洲爪蟾体内(14C)-二甲基亚硝胺的消除情况，以及非洲爪蟾和其他9种两栖动物肝脏对(14C)-二甲基亚硝胺的体外代谢情况。鉴于其从体内快速消除以及非洲爪蟾肝脏体外代谢率低，二甲基亚硝胺在非洲爪蟾中不太可能具有毒性或致癌性。
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