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非洲爪蟾及其他两栖动物对二甲基亚硝胺（DMN）的消除与代谢

Elimination and metabolism of dimethylnitrosamine (DMN) by Xenopus laevis and other amphibians.

作者信息

Rao R R, Clothier R H, Hodgson R M, Balls M

出版信息

Experientia. 1979 Dec 15;35(12):1661-3. doi: 10.1007/BF01953255.

DOI:10.1007/BF01953255
PMID:520492
Abstract

The elimination of (14C)-DMN after i.p. injection into Xenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver from Xenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism by Xenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic in Xenopus.

摘要

测定了腹腔注射(14C)-二甲基亚硝胺后非洲爪蟾体内(14C)-二甲基亚硝胺的消除情况，以及非洲爪蟾和其他9种两栖动物肝脏对(14C)-二甲基亚硝胺的体外代谢情况。鉴于其从体内快速消除以及非洲爪蟾肝脏体外代谢率低，二甲基亚硝胺在非洲爪蟾中不太可能具有毒性或致癌性。

相似文献

1
Elimination and metabolism of dimethylnitrosamine (DMN) by Xenopus laevis and other amphibians.非洲爪蟾及其他两栖动物对二甲基亚硝胺（DMN）的消除与代谢
Experientia. 1979 Dec 15;35(12):1661-3. doi: 10.1007/BF01953255.
2
Modulation of repair of O6-methylguanine in parenchymal and nonparenchymal liver cells of rats treated with dimethylnitrosamine.二甲基亚硝胺处理大鼠的实质和非实质肝细胞中O6-甲基鸟嘌呤修复的调节
Cancer Res. 1985 Oct;45(10):4768-73.
3
Comparative in vitro metabolisms of dimethylnitrosamine in animals of six different species.六种不同物种动物体内二甲基亚硝胺的体外代谢比较
J Environ Pathol Toxicol. 1980 Nov;4(5-6):229-35.
4
Dimethylnitrosamine genotoxicity in rat liver primary cell cultures with low cytochrome P-450 levels.细胞色素P - 450水平低的大鼠肝脏原代细胞培养物中二甲亚硝胺的遗传毒性
J Appl Toxicol. 1984 Dec;4(6):297-303. doi: 10.1002/jat.2550040604.
5
Effects of pyrazole and 3-amino-1,2,4-triazole on the metabolism and toxicity of dimethylnitrosamine in the rat.吡唑和3-氨基-1,2,4-三唑对大鼠体内二甲基亚硝胺代谢及毒性的影响
J Natl Cancer Inst. 1977 Mar;58(3):629-33. doi: 10.1093/jnci/58.3.629.
6
Stability and capacity of dimethylnitrosamine-induced O6-methylguanine repair system in rat liver.二甲基亚硝胺诱导的大鼠肝脏O6-甲基鸟嘌呤修复系统的稳定性和容量
Cancer Res. 1983 Dec;43(12 Pt 1):5808-14.
7
Studies on the metabolism of dimethylnitrosamine in vitro by rat-liver preparations. II. Inhibition by substrates and inhibitors of monoamine oxidase.大鼠肝脏制剂对二甲基亚硝胺的体外代谢研究。II. 单胺氧化酶底物和抑制剂的抑制作用
Xenobiotica. 1982 Sep;12(9):567-79. doi: 10.3109/00498258209038936.
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Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.长期摄入乙醇后二甲基亚硝胺代谢增强并激活为诱变剂。
Cancer Res. 1981 Jan;41(1):120-4.
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Possible formation of nitrosamine in guinea pigs following exposure to nitrogen dioxide and dimethylamine.豚鼠暴露于二氧化氮和二甲胺后可能形成亚硝胺。
J Toxicol Environ Health. 1981 May;7(5):753-63. doi: 10.1080/15287398109530017.
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Oxidative metabolism of dimethylnitrosamine: correlation with toxicity.二甲基亚硝胺的氧化代谢：与毒性的相关性。
J Toxicol Environ Health. 1978 Jan;4(1):161-72. doi: 10.1080/15287397809529653.

本文引用的文献

1
DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO.二乙基亚硝胺诱导斑马鱼肝脏变性和肿瘤形成
J Natl Cancer Inst. 1965 Jan;34:117-30. doi: 10.1093/jnci/34.1.117.
2
The rate of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the rat.大鼠体内甲磺酸甲酯、硫酸二甲酯和N-甲基-N-亚硝基脲的分解速率
Biochem J. 1968 Nov;110(1):49-52. doi: 10.1042/bj1100049.
3
The lethal and hepatocarcinogenic effects of dimethylnitrosamine injection in the newt Triturus helveticus.
二甲基亚硝胺注射对瑞士蝾螈的致死和致癌作用。
Br J Cancer. 1972 Jun;26(3):206-15. doi: 10.1038/bjc.1972.28.
4
Nitroso compounds.亚硝基化合物
Br Med Bull. 1969 Sep;25(3):240-4. doi: 10.1093/oxfordjournals.bmb.a070711.
5
Metabolism of dimethylnitrosamine by amphibians and fish in vitro.两栖动物和鱼类体外对二甲基亚硝胺的代谢
Experientia. 1973 May 15;29(5):599-601. doi: 10.1007/BF01926689.
6
Dimethylnitrosamine-induced hepatic cell carcinoma in rainbow trout.二甲基亚硝胺诱导虹鳟鱼肝细胞癌
J Natl Cancer Inst. 1968 Aug;41(2):531-52.
7
The relationship between cell sizes, respiration rates and survival of amphibian tissues in long-term organ cultures.长期器官培养中两栖动物组织的细胞大小、呼吸速率与存活率之间的关系。
Comp Biochem Physiol A Comp Physiol. 1973 Mar 1;44(3):871-80. doi: 10.1016/0300-9629(73)90150-3.
8
Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.烷基化核苷的形成与代谢：在亚硝基化合物和烷基化剂致癌过程中的可能作用。
Adv Cancer Res. 1977;25:195-269. doi: 10.1016/s0065-230x(08)60635-1.
9
The induction of tumors in Rana temporaria with nitrosamines.用亚硝胺诱发林蛙肿瘤
Neoplasma. 1977;24(3):249-51.