Immunization aginast tetanus with aluminium free-versus aluminium contain triple vaccine.

In order to discover if elimination of aluminium from the very effective triple vaccine gives an unsatisfactory immunity against tetanus, the following investigation has been performed. 47 children were immunized in 1968 and 1969 during the first year of life with 3 injections of aluminium free triple vaccine given with an interval of 4--6 weeks. The vaccine contained 10 Lf tetanus toxoid per dose. 8 years later, during 1976 and 1977, they were given boosters containing aluminium adsorbed Td with 4 Lf tetanus toxoid. The above mentioned group was compared with 29 children immunized in the 1950's in the same way but with aluminium adsorbed triple vaccine (13--19 Lf tetanus toxoid per dose). The booster with DT given 6 to 7 years later contained 8 Lf aluminium adsorbed tetanus toxoid. The serum content of tetanus antitoxin was determined before and after the booster. The result showed that the tetanus immunity was very satisfactory even though the basic immunization was performed with aluminium free triple vaccine.