[7-(氮杂环丁烷-2-羧酸)]-催产素和-赖氨酸加压素的合成及生物活性
Synthesis and biological activities of [7-(azetidine-2-carboxylic acid)]-oxytocin and -lysine-vasopressin.
作者信息
Barber M, Jones J H, Stachulski A V, Bisset G W, Chowdrey H S, Hudson A L
出版信息
Int J Pept Protein Res. 1979;14(3):247-61. doi: 10.1111/j.1399-3011.1979.tb01931.x.
[7-(Azetidine-2-carboxylic acid)]-oxytocin and -lysine-vasopressin have been synthesised by a (6 + 3) strategy using protected hexapeptide acids with preformed disulphide bridges, and their biological activities have been investigated. All activities were reduced but not to the same extent. In assays of pressor and antidiuretic activity it was observed consistently that the responses to the vasopressin analogue were of shorter duration than responses to lysine-vasopressin of the same amplitude.
[7-(氮杂环丁烷-2-羧酸)]-催产素和-赖氨酸-加压素已通过(6 + 3)策略合成，该策略使用具有预先形成的二硫键的保护六肽酸，并对它们的生物活性进行了研究。所有活性均降低，但程度不同。在升压和抗利尿活性测定中，一致观察到对加压素类似物的反应持续时间比相同幅度的赖氨酸-加压素反应持续时间短。
Zotero 插件