家族性肺动脉高压。常染色体显性遗传的证据。
Familial pulmonary hypertension. Evidence of autosomal dominant inheritance.
作者信息
Thompson P, McRae C
出版信息
Br Heart J. 1970 Nov;32(6):758-60. doi: 10.1136/hrt.32.6.758.
Abstract
A patient with primary pulmonary hypertension is the fourth member of a family proven to have the disease. The patient's father married twice; the disease appeared in both families, and was transmitted through two generations. Multiple genetic and environmental factors may result in pulmonary hypertension, but the distribution of cases in this family and in others reported is consistent with the autosomal dominant inheritance of a single genetic trait.
摘要
一名原发性肺动脉高压患者是已被证实患有该病的一个家族中的第四名成员。该患者的父亲结过两次婚；这种疾病在两个家族中均有出现，并遗传了两代人。多种遗传和环境因素可能导致肺动脉高压，但这个家族以及其他已报道家族中的病例分布情况与单一遗传性状的常染色体显性遗传相符。
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