Shimizu M, Sakaue N, Kaito T, Ikeda R
Int Pharmacopsychiatry. 1979;14(3):170-5. doi: 10.1159/000468375.
The relationship between the concentration of lithium in whole blood and plasma was determined in 11 manic-depressive patients 12 h after the evening dose of lithium carbonate taken in the form of slow release tablets (Limas). Significant relationships were found between the concentration of lithium in whole blood and plasma as well as between the daily dose of lithium and the lithium concentration in whole blood and in plasma. The findings suggest that under certain conditions the concentration of lithium in a small sample of whole blood may be used to monitor lithium therapy in outpatients. The advantages of using whole blood are discussed.
对11名躁郁症患者进行了研究，他们在晚上服用缓释片（利马斯）形式的碳酸锂12小时后，测定了全血和血浆中锂的浓度。发现全血和血浆中锂的浓度之间以及锂的日剂量与全血和血浆中锂的浓度之间存在显著关系。研究结果表明，在某些情况下，一小份全血中的锂浓度可用于监测门诊患者的锂治疗。文中讨论了使用全血的优点。
