Grandhi R R, Brown R G, Reinhart B S, Summers J D
Poult Sci. 1975 Mar;54(2):493-9. doi: 10.3382/ps.0540493.
Serum protein profiles were studied together with serum binding sites and capacity for L-thyroxine in dwarf and non-dwarf White Leghorn and White Rock breeds at ages 1 wk., 4 wks. and in laying hens. Serum protein profiles varied with breed, strain and age. The percent gamma-globulin fraction was greater (P less than .05) in dwarf 1 wk. old and laying hens of the White Leghorn breed when compared with the normals. The only difference found in the White Rock breed was a decreased level of albumin in dwarf laying hens. There were no significant differences in the capacity or sites of binding of L-thyroxine to serum proteins although greater amounts of L-thyroxine were bound to globulin fractions in the dwarf. The data were interpreted to suggest that changes in serum protein profiles may have been the result of hypothyroidism at the cellular level but there was no reason to suspect abnormal binding of thyroid hormones to be the cause of that hypothyroidism.
研究了矮小型和正常型白来航鸡及白洛克鸡在1周龄、4周龄时以及产蛋母鸡的血清蛋白谱、血清甲状腺素结合位点和结合能力。血清蛋白谱因品种、品系和年龄而异。与正常鸡相比，1周龄矮小型白来航鸡和产蛋期白来航鸡的γ-球蛋白组分百分比更高（P<0.05）。在白洛克品种中发现的唯一差异是矮小型产蛋母鸡的白蛋白水平降低。虽然矮小型鸡中与球蛋白组分结合的甲状腺素量更多，但甲状腺素与血清蛋白的结合能力或结合位点没有显著差异。这些数据被解释为表明血清蛋白谱的变化可能是细胞水平甲状腺功能减退的结果，但没有理由怀疑甲状腺激素的异常结合是导致甲状腺功能减退的原因。
