Mitchell M D, Anderson A B, Brunt J D, Clover L, Ellwood D A, Robinson J S, Turnbull A C
J Endocrinol. 1979 Nov;83(2):141-8. doi: 10.1677/joe.0.0830141.
The concentrations of 6-oxo-prostaglandin F 1 alpha (6-oxo-PGF 1 alpha) have been determined in maternal and foetal plasma from nine chronically catheterized sheep during late pregnancy and parturition. Labour occurred either spontaneously (three sheep) or was induced by continous intrafoetal infusion of Synacthen (ACTH 1-24; 0.24 mg/24 h; three sheep) or dexamethasone (1 mg/24 h; three sheep). During spontaneous and Synacthen-induced parturition, concentrations of 6-oxo-PGF 1 alpha in maternal and foetal plasma remained at basal levels until 24 h before delivery. At varying times during the 24 h before delivery, levels of 6-oxo-PGF 1 alpha in maternal and foetal plasma were generally increased. When parturition was induced with dexamethasone, however, no increase was observed in the foetal plasma although the concentration of 6-oxo-PGF 1 alpha in maternal plasma was raised close to delivery.
在妊娠晚期和分娩期，对9只长期插管的绵羊的母血和胎血中6-氧代-前列腺素F1α（6-oxo-PGF1α）的浓度进行了测定。分娩为自然发生（3只绵羊），或通过向胎儿持续输注辛纳肽（促肾上腺皮质激素1-24；0.24mg/24小时；3只绵羊）或地塞米松（1mg/24小时；3只绵羊）诱导发生。在自然分娩和辛纳肽诱导的分娩过程中，母血和胎血中6-oxo-PGF1α的浓度在分娩前24小时一直保持在基础水平。在分娩前24小时的不同时间，母血和胎血中6-oxo-PGF1α的水平通常会升高。然而，用地塞米松诱导分娩时，尽管母血中6-oxo-PGF1α的浓度在分娩临近时升高，但胎血中未观察到升高。
