Widmer R B, Cadoret R J
J Fam Pract. 1979 Dec;9(6):1017-21.
This study was done to characterize changes in patient behavior during specific time periods immediately before first, second, third, and fourth episodes of depression. Forty-three patients from a group of 154 depressed patients examined in an earlier study developed 59 subsequent episodes of depression, and these were the patients used in this study. Suitable age and sex matched controls were also examined for the same time periods. The depressed patients and controls were patients in a rural solo practice. The depressed patients showed increased number of patient initiated visits, increased incidence of hospitalization, increased number of functional complaints, increased number of pain complaints, and increased feelings of tension as compared to controls during the seven months prior to the diagnosis date of the first and each succeeding episode of depression. The study results indicate that increased numbers of office visits, functional complaints, pain complaints, and anxiety complaints can be harbingers of a clinical depression, whether it be the index (first) or a subsequent depressive illness.
本研究旨在描述抑郁症首次、第二次、第三次和第四次发作前特定时间段内患者行为的变化。在早期一项研究中接受检查的154名抑郁症患者中有43名患者随后出现了59次抑郁发作,本研究使用的就是这些患者。同时还在相同时间段对年龄和性别匹配的合适对照组进行了检查。抑郁症患者和对照组均来自一位乡村医生的独立诊疗业务。与对照组相比,在首次及随后每次抑郁发作诊断日期前的七个月里,抑郁症患者主动就诊的次数增加、住院率上升、功能障碍主诉增多、疼痛主诉增多且紧张感增强。研究结果表明,无论是首发(首次)还是后续的抑郁症,门诊就诊次数增加、功能障碍主诉、疼痛主诉及焦虑主诉增多都可能是临床抑郁症的先兆。