Walder R, Bradish C J
J Gen Virol. 1979 Aug;44(2):373-82. doi: 10.1099/0022-1317-44-2-373.
Mice of different ages were infected i.p. or i.c. by 23 different strains of VEE virus. The course of the virus host interaction was specified in terms of the efficiency of infection, the outcome of infection as lethality or protection and the survival time. These separately quantifiable features all showed several host-maturation events that combine to provide a multifactorial specification of virus-strains and host-responses. This base-line for correlations with the responses of principal hosts (equidae and man) may be expanded to test correlations with the antigenic or in vitro characteristics of virus-strains.
不同年龄的小鼠通过腹腔注射或脑内注射感染了23种不同株的委内瑞拉马脑炎病毒（VEE病毒）。根据感染效率、感染结果（致死或保护）以及存活时间来明确病毒与宿主相互作用的过程。这些各自可量化的特征均显示出几个宿主成熟事件，这些事件共同构成了对病毒株和宿主反应的多因素描述。这个与主要宿主（马科动物和人类）反应相关的基线可以扩展，以测试与病毒株的抗原或体外特征的相关性。
