Bendixen G, Dickmeiss E, Svejgaard A, Soborg M, Thaysen J H
Scand J Immunol. 1975 Sep;4(5-6):517-25. doi: 10.1111/j.1365-3083.1975.tb02657.x.
The graft-directed, cell-mediated immunity in kidney-allografted patients was examined with a seriologically defined (SD), donor-unrelated panel of antigenic material in clinical steady state, soon after transplantation, and during acute rejection episodes. The SD antigens were selected from the panel on the basis of predictions hypothesized from the SD match of donor and recipient. The cell-mediated immunity was measured by the direct leukocyte migration agarose test (LMAT). Positive reactions in kidney-transplanted patients were induced particularly by one preparation (antigen 52) and were unpredictable on the basis of SD classification. The investigation shows that other antigenic determinants, different from SD antigens, probably play an important role as inducers of cell-mediated, graft-associated immunity in kidney-transplanted patients.
采用一组血清学定义的、与供者无关的抗原物质，在临床稳定状态下、移植后不久以及急性排斥反应期间，对肾移植患者的移植物定向细胞介导免疫进行了检测。根据供者与受者的血清学配型所做的假设预测，从该组中选择血清学定义（SD）抗原。通过直接白细胞迁移琼脂糖试验（LMAT）测定细胞介导免疫。肾移植患者的阳性反应尤其由一种制剂（抗原52）诱导产生，且根据SD分类无法预测。该研究表明，与SD抗原不同的其他抗原决定簇，可能在肾移植患者中作为细胞介导的移植物相关免疫的诱导剂发挥重要作用。
