Motor innervation of the gastrocnemius muscle of wobbler and dystrophic mice.

Innervation of the gastrocnemius muscle of mice from the wobbler, dystrophic and C57/BL colonies has been studied. It was found that phenotypically normal mice from each of the colonies did not differ in their innervation properties, hence suggesting no heterozygote penetrance. However, the end-plate complexity increased with age of normal mice. Functional terminal innervation ratio for both the wobbler and dystrophic gastrocnemius muscle was raised above that of the normal and many dystrophic end-plates also appeared abnormal. A study of mice from the wobbler colony manifesting a late onset hind-limb muscle degeneration (Wr/HLD) has been included and the results suggest a relatively benign form of spinal muscular atrophy.