Smith M J, Bolam J P
J Pathol. 1979 Oct;129(2):65-71. doi: 10.1002/path.1711290204.
A selective accumulation of blood platelets occurs at the sites of intradermal injection of zymosan and carrageenan in the rat. The inflammatory response to zymosan, assessed by the local accumulation of systemic radioactive human serum albumin, was significantly enhanced in platelet-depleted rats. Similar enhancements of the paw oedemas, caused by the subplantar injection of either carrageenan or zymosan, were also observed in thrombocytopenic animals. It is concluded that blood platelets may exert protective, i.e., anti-inflammatory, effects in some models of acute inflammation in the rat.
在大鼠皮内注射酵母聚糖和角叉菜胶的部位会出现血小板的选择性聚集。通过全身放射性人血清白蛋白的局部聚集来评估，血小板减少的大鼠对酵母聚糖的炎症反应显著增强。在血小板减少的动物中，也观察到由足底注射角叉菜胶或酵母聚糖引起的爪部水肿有类似增强。得出的结论是，在大鼠急性炎症的某些模型中，血小板可能发挥保护作用，即抗炎作用。
