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1
Conformation and reaction specificity in pyridoxal phosphate enzymes.磷酸吡哆醛酶中的构象与反应特异性。
Proc Natl Acad Sci U S A. 1966 Apr;55(4):712-6. doi: 10.1073/pnas.55.4.712.
2
Coenzymatic activity of homologues of pyridoxal phosphate.磷酸吡哆醛同系物的辅酶活性。
Proc Natl Acad Sci U S A. 1967 Jun;57(6):1692-9. doi: 10.1073/pnas.57.6.1692.
3
Pyridoxal phosphate. 3. Pyrimidine analogs. 3-(Substituted 5-pyrimidyl)propionic acids as potential inhibitory analogs of pyridoxal phosphate.
J Med Chem. 1969 May;12(3):424-6. doi: 10.1021/jm00303a019.
4
Pyridoxal 5'-phosphate enzymes. Influence of substrate concentration on the pH optimum of enzyme reactions involving transaldimination.磷酸吡哆醛酶。底物浓度对涉及转醛亚胺化的酶反应最适pH值的影响。
Hoppe Seylers Z Physiol Chem. 1967 Dec;348(12):1730-3.
5
A proposed structure for the 330 -nm chromophore of glutamate decarboxylase and other pyridoxal 5'-phosphate dependent enzymes.谷氨酸脱羧酶及其他依赖磷酸吡哆醛的酶的330纳米发色团的一种推测结构。
Biochim Biophys Acta. 1971 Aug 20;242(2):484-92. doi: 10.1016/0005-2744(71)90241-5.
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[Immobilization of some vitamin B6-dependent enzymes and vitamin B12-dependent diol dehydrase. Application to studies on their structure-function relationships (author's transl)].某些维生素B6依赖性酶和维生素B12依赖性二醇脱水酶的固定化。在其结构-功能关系研究中的应用(作者译)
Seikagaku. 1976;48(2):96-117.
7
Pyridoxal phosphate. II. Benzene analogs. 2-Formylphenoxyacetic acids as potential antimetabolites of pyridoxal phosphate.磷酸吡哆醛。II. 苯类似物。2-甲酰基苯氧基乙酸作为磷酸吡哆醛的潜在抗代谢物
J Med Chem. 1969 May;12(3):420-4. doi: 10.1021/jm00303a018.
8
Stereochemical aspects of pyridoxal phosphate catalysis.磷酸吡哆醛催化作用的立体化学方面
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9
[STUDY ON THE STABILITY OF 5'-PHOSPHOPYRIDOXAL ISONICOTINOYLHYDRAZONE IN THE PRESENCE OF PYRIDOXAL ENZYMES].[吡哆醛酶存在下5'-磷酸吡哆醛异烟酰腙的稳定性研究]
Bull Soc Chim Biol (Paris). 1964 May 5;46:323-8.
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[Influence of pyridoxal phosphate and some other pyridoxine derivatives on stability, in vitro, of cystathionase and cysteine sulfinic acid decarboxylase].[磷酸吡哆醛及其他一些吡哆醇衍生物对胱硫醚酶和半胱氨酸亚磺酸脱羧酶体外稳定性的影响]
Bull Soc Chim Biol (Paris). 1968 Mar 2;50(1):129-41.

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α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery?α-肼基酸通过“催化正确”的酮烯胺互变异构体抑制磷酸吡哆醛依赖性脱羧酶:化学生物学和药物发现的一个特殊基序?
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Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability.热稳定α-氧代胺合酶生物催化剂的合理工程改造扩展了底物范围和合成适用性。
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Pyridoxal-Inspired Photo-Decarboxylase Catalysis: Photochemical Decarboxylation of Unprotected Amino Acids.基于吡哆醛的光脱羧酶催化作用:未保护氨基酸的光化学脱羧反应
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Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes.磷酸吡哆醛依赖性酶介导林可酰胺生物合成多样化的分子基础。
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Biochemical Studies on Human Ornithine Aminotransferase Support a Cell-Based Enzyme Replacement Therapy in the Gyrate Atrophy of the Choroid and Retina.人鸟氨酸转氨酶的生化研究支持基于细胞的酶替代疗法治疗神经氨酸苷贮积症。
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Active-Site Oxygen Accessibility and Catalytic Loop Dynamics of Plant Aromatic Amino Acid Decarboxylases from Molecular Simulations.基于分子模拟的植物芳香族氨基酸脱羧酶活性位点氧可及性和催化环动力学研究。
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Neutron diffraction from a microgravity-grown crystal reveals the active site hydrogens of the internal aldimine form of tryptophan synthase.来自微重力生长晶体的中子衍射揭示了色氨酸合酶内部醛亚胺形式的活性位点氢原子。
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One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse.一种底物多种酶的虚拟筛选揭示了人和小鼠肉碱生物合成中缺失的基因。
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An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction.一个N⋯H⋯N低势垒氢键使天冬氨酸转氨酶的催化位点预组织,以促进后半反应。
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本文引用的文献

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D-Alanine formation; a racemase in Streptococcus faecalis.D-丙氨酸的形成;粪肠球菌中的一种消旋酶。
J Biol Chem. 1951 May;190(1):403-16.
2
Pyridoxal-catalyzed decarboxylation of amino acids.吡哆醛催化的氨基酸脱羧反应。
Biochemistry. 1962 Jul;1:594-600. doi: 10.1021/bi00910a008.
3
SERINE TRANSHYDROXYMETHYLASE. PROPERTIES OF THE ENZYME-SUBSTRATE COMPLEXES OF D-ALANINE AND GLYCINE.
J Biol Chem. 1964 Nov;239:3801-7.
4
CONTROL OF ASPARTATE BETA-DECARBOXYLASE ACTIVITY BY TRANSAMINATION.通过转氨作用对天冬氨酸β-脱羧酶活性的控制
J Biol Chem. 1964 Mar;239:879-88.
5
Evidence for the participation of FAD in the alanine racemase (EC 5.1.1.1) reaction.
Biochim Biophys Acta. 1963 Jan 8;67:161-3. doi: 10.1016/0006-3002(63)91810-9.
6
Glutamic acid racemase from Lactobacillus arabinosus.
J Biol Chem. 1960 Jul;235:2095-8.
7
Electronic aspects of the reactions of pyridoxal phosphate enzymes.磷酸吡哆醛酶反应的电子学方面
Biochim Biophys Acta. 1961 Jan 29;46:555-75. doi: 10.1016/0006-3002(61)90586-8.
8
Chemical structure in relation to biological activities of vitamin B6.与维生素B6生物活性相关的化学结构
Vitam Horm. 1958;16:77-125. doi: 10.1016/s0083-6729(08)60314-3.
9
[Theory on amino acid metabolism processes catalyzed by pyridoxine enzymes].[关于由吡哆醇酶催化的氨基酸代谢过程的理论]
Biokhimiia. 1953 Jul-Aug;18(4):393-411.

Conformation and reaction specificity in pyridoxal phosphate enzymes.

作者信息

Dunathan H C

出版信息

Proc Natl Acad Sci U S A. 1966 Apr;55(4):712-6. doi: 10.1073/pnas.55.4.712.

DOI:10.1073/pnas.55.4.712
PMID:5219675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC224217/
Abstract
摘要