Conformation and reaction specificity in pyridoxal phosphate enzymes.
作者信息
Dunathan H C
出版信息
Proc Natl Acad Sci U S A. 1966 Apr;55(4):712-6. doi: 10.1073/pnas.55.4.712.
Abstract
摘要
相似文献
1
Conformation and reaction specificity in pyridoxal phosphate enzymes.磷酸吡哆醛酶中的构象与反应特异性。
Proc Natl Acad Sci U S A. 1966 Apr;55(4):712-6. doi: 10.1073/pnas.55.4.712.
2
Coenzymatic activity of homologues of pyridoxal phosphate.磷酸吡哆醛同系物的辅酶活性。
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Pyridoxal phosphate. 3. Pyrimidine analogs. 3-(Substituted 5-pyrimidyl)propionic acids as potential inhibitory analogs of pyridoxal phosphate.
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Pyridoxal 5'-phosphate enzymes. Influence of substrate concentration on the pH optimum of enzyme reactions involving transaldimination.磷酸吡哆醛酶。底物浓度对涉及转醛亚胺化的酶反应最适pH值的影响。
Hoppe Seylers Z Physiol Chem. 1967 Dec;348(12):1730-3.
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A proposed structure for the 330 -nm chromophore of glutamate decarboxylase and other pyridoxal 5'-phosphate dependent enzymes.谷氨酸脱羧酶及其他依赖磷酸吡哆醛的酶的330纳米发色团的一种推测结构。
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6
7
Pyridoxal phosphate. II. Benzene analogs. 2-Formylphenoxyacetic acids as potential antimetabolites of pyridoxal phosphate.磷酸吡哆醛。II. 苯类似物。2-甲酰基苯氧基乙酸作为磷酸吡哆醛的潜在抗代谢物
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Stereochemical aspects of pyridoxal phosphate catalysis.磷酸吡哆醛催化作用的立体化学方面
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[STUDY ON THE STABILITY OF 5'-PHOSPHOPYRIDOXAL ISONICOTINOYLHYDRAZONE IN THE PRESENCE OF PYRIDOXAL ENZYMES].[吡哆醛酶存在下5'-磷酸吡哆醛异烟酰腙的稳定性研究]
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[Influence of pyridoxal phosphate and some other pyridoxine derivatives on stability, in vitro, of cystathionase and cysteine sulfinic acid decarboxylase].[磷酸吡哆醛及其他一些吡哆醇衍生物对胱硫醚酶和半胱氨酸亚磺酸脱羧酶体外稳定性的影响]
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本文引用的文献
1
D-Alanine formation; a racemase in Streptococcus faecalis.D-丙氨酸的形成；粪肠球菌中的一种消旋酶。
J Biol Chem. 1951 May;190(1):403-16.
2
Pyridoxal-catalyzed decarboxylation of amino acids.吡哆醛催化的氨基酸脱羧反应。
Biochemistry. 1962 Jul;1:594-600. doi: 10.1021/bi00910a008.
3
SERINE TRANSHYDROXYMETHYLASE. PROPERTIES OF THE ENZYME-SUBSTRATE COMPLEXES OF D-ALANINE AND GLYCINE.
J Biol Chem. 1964 Nov;239:3801-7.
4
CONTROL OF ASPARTATE BETA-DECARBOXYLASE ACTIVITY BY TRANSAMINATION.通过转氨作用对天冬氨酸β-脱羧酶活性的控制
J Biol Chem. 1964 Mar;239:879-88.
5
Evidence for the participation of FAD in the alanine racemase (EC 5.1.1.1) reaction.
Biochim Biophys Acta. 1963 Jan 8;67:161-3. doi: 10.1016/0006-3002(63)91810-9.
6
Glutamic acid racemase from Lactobacillus arabinosus.
J Biol Chem. 1960 Jul;235:2095-8.
7
Electronic aspects of the reactions of pyridoxal phosphate enzymes.磷酸吡哆醛酶反应的电子学方面
Biochim Biophys Acta. 1961 Jan 29;46:555-75. doi: 10.1016/0006-3002(61)90586-8.
8
Chemical structure in relation to biological activities of vitamin B6.与维生素B6生物活性相关的化学结构
Vitam Horm. 1958;16:77-125. doi: 10.1016/s0083-6729(08)60314-3.
9
[Theory on amino acid metabolism processes catalyzed by pyridoxine enzymes].[关于由吡哆醇酶催化的氨基酸代谢过程的理论]
Biokhimiia. 1953 Jul-Aug;18(4):393-411.
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