Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.
作者信息
Flexner L B, Flexner J B
出版信息
Proc Natl Acad Sci U S A. 1966 Feb;55(2):369-74. doi: 10.1073/pnas.55.2.369.
Abstract
摘要
相似文献
1
Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.乙酰氧基环己酰亚胺及乙酰氧基环己酰亚胺-嘌呤霉素混合物对小鼠脑蛋白质合成及记忆的影响。
Proc Natl Acad Sci U S A. 1966 Feb;55(2):369-74. doi: 10.1073/pnas.55.2.369.
2
Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory.用抗生素分析小鼠的记忆。抗生素对于研究记忆阶段以及揭示维持记忆的分子事件很有用。
Science. 1967 Mar 17;155(3768):1377-83. doi: 10.1126/science.155.3768.1377.
3
Loss of memory in mice as related to regional inhibition of cerebral protein synthesis.
Tex Rep Biol Med. 1966 Spring;24(1):3-19.
4
Comparative effects of cycloheximide and puromycin on cerebral protein synthesis and consolidation of memory in mice.放线菌酮和嘌呤霉素对小鼠大脑蛋白质合成及记忆巩固的比较作用
Brain Res. 1967 Feb;4(1):44-51. doi: 10.1016/0006-8993(67)90147-3.
5
Further studies on the effects of blocking agents on protein synthesis in goldfish brain.关于阻断剂对金鱼脑蛋白质合成影响的进一步研究。
J Neurochem. 1970 Dec;17(12):1637-47. doi: 10.1111/j.1471-4159.1970.tb11388.x.
6
The effect of memory blocking antibiotics and their analogs on acetylcholinesterase.记忆阻断性抗生素及其类似物对乙酰胆碱酯酶的影响。
Pharmacol Biochem Behav. 1976 Jul;5(1):1-3. doi: 10.1016/0091-3057(76)90278-1.
7
Puromycin: action on neuronal mitochondria.嘌呤霉素：对神经元线粒体的作用
Science. 1968 Aug 30;161(3844):900-2. doi: 10.1126/science.161.3844.900.
8
Elevation of REM sleep following inhibition of protein synthesis.
Brain Res. 1972 Nov 27;47(1):254-8. doi: 10.1016/0006-8993(72)90266-1.
9
Radioautographic localization of inhibition of protein synthesis in specific regions of monkey brain.
Brain Res. 1973 Oct 26;61:438-41. doi: 10.1016/0006-8993(73)90553-2.
10
Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning.在学习前或学习后立即用乙酰氧基环己酰亚胺处理的小鼠的记忆阶段。
Proc Natl Acad Sci U S A. 1966 Aug;56(2):730-5. doi: 10.1073/pnas.56.2.730.
引用本文的文献
1
Gut microbiome and host TOR pathway interact to regulate predator-induced aversive memory in .肠道微生物群与宿主的TOR通路相互作用，以调节（某种生物中）捕食者诱导的厌恶记忆。
Proc Natl Acad Sci U S A. 2025 Jun 24;122(25):e2422928122. doi: 10.1073/pnas.2422928122. Epub 2025 Jun 20.
2
Dynamics of two distinct memory interactions during water seeking in .在……中寻找水源时两种不同记忆相互作用的动态变化 。 （原文句子不完整，翻译可能不太能完全表意准确）
Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2422028122. doi: 10.1073/pnas.2422028122. Epub 2025 Apr 17.
3
Persistent transcriptional programmes are associated with remote memory.持久的转录程序与远程记忆有关。
Nature. 2020 Nov;587(7834):437-442. doi: 10.1038/s41586-020-2905-5. Epub 2020 Nov 11.
4
Critical period of memory enhancement during taste avoidance conditioning in Lymnaea stagnalis.椎实螺味觉回避条件反射过程中记忆增强的关键期
PLoS One. 2013 Oct 3;8(10):e75276. doi: 10.1371/journal.pone.0075276. eCollection 2013.
5
The role of protein synthesis in memory consolidation: progress amid decades of debate.蛋白质合成在记忆巩固中的作用：历经数十年争论后的进展。
Neurobiol Learn Mem. 2008 Mar;89(3):293-311. doi: 10.1016/j.nlm.2007.09.010. Epub 2007 Nov 28.
6
Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning.长期记忆所需的蛋白质合成是在联想学习前几天由蛋白激酶C激活诱导产生的。
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16432-7. doi: 10.1073/pnas.0508001102. Epub 2005 Oct 28.
7
The fine structure of puromycin-induced changes in mouse entorhinal cortex.嘌呤霉素诱导的小鼠内嗅皮质变化的精细结构
J Cell Biol. 1968 Feb;36(2):379-90. doi: 10.1083/jcb.36.2.379.
8
[Learning and memory--experiments with the honey bee].
Naturwissenschaften. 1970 Oct;57(10):463-7. doi: 10.1007/BF00593072.
9
Further observations on restoration of memory lost after treatment with puromycin.关于嘌呤霉素治疗后失忆恢复情况的进一步观察
Yale J Biol Med. 1969;42(3-4):235-40.
10
Studies on memory: distribution of peptidyl-puromycin in subcellular fractions of mouse brain.记忆研究：肽基嘌呤霉素在小鼠脑亚细胞组分中的分布
Proc Natl Acad Sci U S A. 1971 Jan;68(1):26-8. doi: 10.1073/pnas.68.1.26.
本文引用的文献
1
ROLE OF THE GENETIC MESSAGE IN POLYRIBOSOME FUNCTION.遗传信息在多核糖体功能中的作用。
J Mol Biol. 1965 Feb;11:358-72. doi: 10.1016/s0022-2836(65)80063-8.
2
BREAKDOWN AND REASSEMBLY OF RAT LIVER ERGOSOMES AFTER ADMINISTRATION OF ETHIONINE OR PUROMYCIN.给予乙硫氨酸或嘌呤霉素后大鼠肝脏微粒体的分解与重新组装
J Biol Chem. 1964 Nov;239:3826-33.
3
LOSS OF RECENT MEMORY IN MICE AS RELATED TO REGIONAL INHIBITION OF CEREBRAL PROTEIN SYNTHESIS.小鼠近期记忆丧失与大脑蛋白质合成的区域抑制有关。
Proc Natl Acad Sci U S A. 1964 Nov;52(5):1165-9. doi: 10.1073/pnas.52.5.1165.
4
CHANGES IN RNA CONTENT AND BASE COMPOSITION IN CORTICAL NEURONS OF RATS IN A LEARNING EXPERIMENT INVOLVING TRANSFER OF HANDEDNESS.在涉及 handedness 转换的学习实验中大鼠皮质神经元中 RNA 含量和碱基组成的变化 。
注：这里的“handedness”可能是一个特定专业领域里关于某种“用手习惯”之类的术语，原英文表述不太常见准确的日常用词，推测其在专业语境里有特定含义，以上译文是按照字面翻译，供你参考。
Proc Natl Acad Sci U S A. 1964 Oct;52(4):1030-5. doi: 10.1073/pnas.52.4.1030.
5
EFFECT OF CYCLOHEXIMIDE ON RIBOSOMAL AGGREGATES ENGAGED IN PROTEIN SYNTHESIS IN VITRO.环己酰亚胺对体外参与蛋白质合成的核糖体聚集体的影响。
Biochim Biophys Acta. 1964 Jul 22;87:525-8. doi: 10.1016/0926-6550(64)90131-8.
6
CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.环己酰亚胺：哺乳动物细胞中蛋白质合成抑制的相关方面
Science. 1964 Dec 11;146(3650):1474-6. doi: 10.1126/science.146.3650.1474.
7
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.嘌呤霉素对蛋白质合成的抑制作用：嘌呤霉素掺入肽链的过程。
Proc Natl Acad Sci U S A. 1964 Apr;51(4):585-92. doi: 10.1073/pnas.51.4.585.
8
INHIBITION OF PROTEIN SYNTHESIS IN VITRO BY CYCLOHEXIMIDE.环己酰亚胺对体外蛋白质合成的抑制作用。
Nature. 1963 Nov 16;200:675-6. doi: 10.1038/200675a0.
9
INHIBITION OF THE SYNTHESIS OF PROTEIN IN INTACT ANIMALS BY ACETOXYCYCLOHEXIMIDE AND A METABOLIC DERANGEMENT CONCOMITANT WITH THIS BLOCKADE.乙酰氧基环己酰亚胺对完整动物体内蛋白质合成的抑制作用以及伴随这种阻断的代谢紊乱。
Biochem Pharmacol. 1963 Aug;12:855-65. doi: 10.1016/0006-2952(63)90116-3.
10
Memory in mice as affected by intracerebral puromycin.脑内嘌呤霉素对小鼠记忆的影响
Science. 1963 Jul 5;141(3575):57-9. doi: 10.1126/science.141.3575.57.
Zotero 插件