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豚鼠血清中的天然抗体在体外和体内对小鼠淋巴瘤细胞的作用。

The effect of natural antibody in guinea-pig serum on mouse lymphoma cells in vitro and in vivo.

作者信息

Wakefield J D, Batchelor J R

出版信息

Immunology. 1966 Nov;11(5):441-51.

PMID:5224352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423805/
Abstract

Normal guinea-pig serum was found to have a cytotoxic effect upon several newly induced mouse lymphoblastic leukaemias and on normal mouse thymocytes. This reaction was complement dependent, and cross-absorption experiments showed that the reactivity could be abolished by absorption with any susceptible cell type. It was concluded that normal guinea-pig serum contained a natural antibody which reacted in common with normal mouse thymocytes and certain lymphomas. The growth of lymphomas which had proved highly sensitive to guinea-pig serum was inhibited by guinea-pig serum . In contrast, lymphomas showing insensitivity to guinea-pig serum were also insensitive to it . It is suggested that the inhibition of lymphoma growth was due to the natural cytotoxic antibody present in guinea-pig serum.

摘要

研究发现，正常豚鼠血清对几种新诱导的小鼠淋巴细胞白血病以及正常小鼠胸腺细胞具有细胞毒性作用。该反应依赖补体，交叉吸收实验表明，用任何敏感细胞类型进行吸收均可消除其反应性。由此得出结论，正常豚鼠血清中含有一种天然抗体，它能与正常小鼠胸腺细胞和某些淋巴瘤发生共同反应。对豚鼠血清高度敏感的淋巴瘤的生长受到豚鼠血清的抑制。相比之下，对豚鼠血清不敏感的淋巴瘤对其也不敏感。有人认为，淋巴瘤生长受到抑制是由于豚鼠血清中存在天然细胞毒性抗体。

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IMMUNE LYSIS OF THYMUS AND SPLEEN CELLS OF EMBRYONIC AND NEONATAL MICE.胚胎及新生小鼠胸腺和脾细胞的免疫溶解
J Immunol. 1965 Mar;94:358-64.
2
IMMUNOLOGY OF EXPERIMENTAL TUMORS.实验性肿瘤的免疫学
Annu Rev Med. 1964;15:167-86. doi: 10.1146/annurev.me.15.020164.001123.
3
Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. II. Lymphoma 6C3HED cells cultured in a medium devoid of L-asparagine lose their susceptibility to the effects of guinea pig serum in vivo.豚鼠血清中的L-天冬酰胺酶是其抗淋巴瘤作用的原因的证据。II. 在不含L-天冬酰胺的培养基中培养的淋巴瘤6C3HED细胞对豚鼠血清在体内的作用失去敏感性。
J Exp Med. 1963 Jul;118(1):121-48. doi: 10.1084/jem.118.1.121.
4
Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance.豚鼠血清中的L-天冬酰胺酶对其抗淋巴瘤作用负责的证据。I. 豚鼠血清L-天冬酰胺酶与抗淋巴瘤物质相关的特性。
J Exp Med. 1963 Jul;118(1):99-120. doi: 10.1084/jem.118.1.99.
5
Inhibitory effect of guinea pig serum on a number of new leukaemias in mice.豚鼠血清对小鼠多种新型白血病的抑制作用。
Nature. 1963 May 25;198:800. doi: 10.1038/198800a0.
6
Leukaemia-inhibiting properties and L-asparaginase activity of sera from certain South American rodents.某些南美啮齿动物血清的白血病抑制特性及L-天冬酰胺酶活性
Nature. 1963 May 25;198:801. doi: 10.1038/198801a0.
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Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. II. Studies on the nature of the active serum constituent: histological mechanism of the regression: tests for effects of guinea pig serum on lymphoma cells in vitro: discussion.用正常豚鼠血清诱导体内移植性淋巴瘤的消退。II. 活性血清成分的性质研究：消退的组织学机制：豚鼠血清对体外淋巴瘤细胞作用的试验：讨论。
J Exp Med. 1953 Dec;98(6):583-606. doi: 10.1084/jem.98.6.583.
8
Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum.通过正常豚鼠血清在体内诱导的移植性淋巴瘤的消退。I. 给小鼠和大鼠注射豚鼠血清、马血清或兔血清后各类移植癌的病程。
J Exp Med. 1953 Dec;98(6):565-82. doi: 10.1084/jem.98.6.565.
9
Alterations in protein and nucleic acid metabolism of lymphoma 6C3HED-og cells in mice given guinea pig serum.给小鼠注射豚鼠血清后淋巴瘤6C3HED-og细胞蛋白质和核酸代谢的变化
J Exp Med. 1966 Jan 1;123(1):55-74. doi: 10.1084/jem.123.1.55.

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