Icard C, Beaupain R, Diatloff C, Macieira-Coelho A
Mech Ageing Dev. 1979 Nov;11(4):269-78. doi: 10.1016/0047-6374(79)90006-x.
The sensitivity to low dose rate ionizing radiation increases progressively through the lifespan of human embryonic lung fibroblasts. There is also an increase in the number of alkali-sensitive sites leading to an increase in single-strand breaks and in DNA with low molecular weight during cell lysis. These DNA changes become pronounced at the very end of the lifespan. The correlation between aging, increased radiosensitivity and accumulation of DNA damage is discussed.
人类胚胎肺成纤维细胞在其寿命期间，对低剂量率电离辐射的敏感性会逐渐增加。在细胞裂解过程中，碱敏感位点的数量也会增加，导致单链断裂以及低分子量DNA的数量增多。这些DNA变化在细胞寿命即将结束时变得十分明显。本文讨论了衰老、辐射敏感性增加与DNA损伤积累之间的相关性。
