脾脏照射治疗慢性粒细胞白血病的作用机制。
The mechanism of action of splenic irradiation in chronic myelogenous leukemia.
作者信息
Galbraith P R
出版信息
Can Med Assoc J. 1967 Jun 24;96(25):1636-41.
The mechanism of action of splenic irradiation in the induction of a remission in chronic myelogenous leukemia was investigated in six patients using a leukocyte kinetic approach. The leukocytes were labelled in vitro with radioactive diisopropylfluorophosphate-32 and returned to the circulation. The effect of treatment on the rate of change of leukocyte specific activity was determined. The results suggest (1) that irradiation of the spleen damages granulopoietic cells as they cycle back and forth between the spleen, blood and other extravascular compartments; (2) that damage to exchangeable granulopoietic cells in transit through the irradiated spleen may explain the long remission often encountered after this form of therapy.
采用白细胞动力学方法，对6例慢性粒细胞白血病患者进行研究，以探讨脾脏照射诱导缓解的作用机制。白细胞在体外被放射性二异丙基氟磷酸-32标记后再返回循环系统。测定治疗对白细胞比活性变化率的影响。结果表明：（1）脾脏照射会损害在脾脏、血液和其他血管外腔室之间循环的粒细胞生成细胞；（2）照射脾脏时，对循环中的可交换粒细胞生成细胞的损伤可能解释了这种治疗方式后常出现的长期缓解现象。
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