Fehér T, Koref O, Tankó A, Bodrogi L, Poteczin E
Arzneimittelforschung. 1975 Aug;25(8):1314-7.
A method has been presented for the quantitative determination of 21-deoxy-N-(N'-methyl-piperazinyl)-prednisolone (Depersolone), a water soluble corticosteroid, and one of its metabolites, prednisolone, in human urine. Following administration of 30 or 90 mg Depersolone i.v., the dynamic appearance of this hormone and the prednisolone metabolite, their biological half-lives and the effect of the synthetic corticosteroid on the excretion of grouped and individual 17-ketosteroids were determined. Results of experiments revealed a dose dependent excretion of the unchanged hormone and a biological half-life 12 to 23 h in control subjects. Prednisolone as a metabolite seems to play a minor role in Depersolone action. The excretion rate of Depersolone was greater and its half-life less than normal in hepatopathies. The dynamic appearance of the hormone was found slow in the urine of patients with prolonged corticosteroid therapy.
已提出一种定量测定人尿中水溶性皮质类固醇21-脱氧-N-(N'-甲基-哌嗪基)-泼尼松龙（地泼罗酮）及其代谢物之一泼尼松龙的方法。静脉注射30或90毫克地泼罗酮后，测定了该激素和泼尼松龙代谢物的动态出现情况、它们的生物半衰期以及合成皮质类固醇对分组和个体17-酮类固醇排泄的影响。实验结果显示，在对照受试者中，未改变的激素排泄呈剂量依赖性，生物半衰期为12至23小时。泼尼松龙作为代谢物在地泼罗酮的作用中似乎起次要作用。在肝病患者中，地泼罗酮的排泄率更高，半衰期比正常情况短。在长期接受皮质类固醇治疗的患者尿液中，发现该激素的动态出现较慢。
