米兰自发性高血压大鼠的肾激肽释放酶和磷脂酶活性

Kidney kallikrein and phospholipase activities in Milan spontaneously hypertensive rats.

作者信息

Baggio B, Favaro S, Piccoli A, Borsatti A

出版信息

Prostaglandins. 1979 Jul;18(1):83-92. doi: 10.1016/s0090-6980(79)80026-x.

Abstract

Renal kallikrein and phospholipase activities were evaluated in a strain of spontaneously hypertensive rats developed by Dr. Bianchi in Milan (MHR). MHR showed lower than normal kallikrein and phospholipase activities before, at 3 weeks of age and following the development of hypertension. Kallikrein and phospholipase activities were directly correlated both in normotensive and spontenously hypertensive rats. The data suggest that MHR have a genetic defect in kallikrein and phospholipase activities, which may play a pathogenetic role in the development of high blood pressure.

摘要

对米兰的比安奇博士培育的一种自发性高血压大鼠品系（MHR）的肾激肽释放酶和磷脂酶活性进行了评估。MHR在3周龄时、高血压形成之前以及形成之后，其激肽释放酶和磷脂酶活性均低于正常水平。在正常血压大鼠和自发性高血压大鼠中，激肽释放酶和磷脂酶活性均呈直接相关。这些数据表明，MHR在激肽释放酶和磷脂酶活性方面存在遗传缺陷，这可能在高血压的发生发展中起致病作用。