[Mechanism of the natriuretic and diuretic action of neurohypophyseal hormones].

Administration to rats against the background of spontaneous urine excretion of pituitrine, vaso pressin and oxytocine caused a diuretic and natriuretic effect on account of the reduction of the tubular reabsorption. In rats with removed adrenal glands the preparations under study did not produce any diuretic influence, and natriuresis was observed only in administration of vas opressin. The diuretic effect of the preparations was absent against the background of hypophysectomy, whereas the natridiuretic effect was retained. It is supposed that the diuretic influence of the neurohypophyseal hormones was associated with the activation of the hypophysis-adrenal system, and some other additional mechanism took part in the natridiuretic effect.