Vanuxem D, Fornaris E, Guillot C, Nicoli M M, Grimaud C
Respiration. 1979;38(4):213-20. doi: 10.1159/000194083.
This study investigated the changes in hemoglobin affinity for oxygen -- P50 standard [P50 (7.40)]; P50 in vivo (P50 IV), and 2,3-diphosphoglycerate concentration (2,3-DPG) -- and the anaerobic metabolism during a short muscular exercise in 20 silicotic patients. P50 (7.40) and 2,3-DPG remained unchanged at the end of the exercise but P50 IV increased significantly. A negative correlation was found between the increase in the arterial lactates and the increase in P50 IV. Such a shift to the right of the oxyhemoglobin dissociation curve probably improves the tissular oxygenation and can be regarded as a compensatory mechanism in patients with pulmonary impairment during exercise.
本研究调查了20例矽肺患者在短时间肌肉运动期间血红蛋白对氧的亲和力变化——P50标准值[P50(7.40)]、体内P50(P50 IV)和2,3 -二磷酸甘油酸浓度(2,3 - DPG)——以及无氧代谢情况。运动结束时，P50(7.40)和2,3 - DPG保持不变，但P50 IV显著增加。动脉血乳酸增加与P50 IV增加之间呈负相关。氧合血红蛋白解离曲线的这种右移可能改善组织氧合，可被视为运动期间肺功能受损患者的一种代偿机制。
