Olsen U B, Magnussen M P, Eilertsen E
Scand J Clin Lab Invest. 1979 May;39(3):265-9. doi: 10.1080/00365517909106104.
Ten dogs received 1 l of 37 degrees C tap water by stomach tube. Urine flow rate increased from 17 +/- 6 ml in the control hour to 285 +/- 25 ml in the second hour following the water intake. The diuresis was paralleled by increased urine kinin excretion from 23 +/- 9 ng/h to 94 +/- 17 ng/h. Urine kallikrein and urine sodium excretions remained unmodified. In seven dogs urine sodium excretion was increased from 0.87 +/- 0.22 mmol/h to 14.9 +/- 1.9 mmol/h by intragastric administration of 2% NaCl. Urine flow moderately increased from 15.1 +/- 2.5 ml/h to 64.3 +/- 15.0 ml/h. Urine kinin excretion was unchanged. The results suggest a relationship between high rates of urine flow and urinary kinin excretion.
十只狗通过胃管接受了1升37摄氏度的自来水。尿量从对照期的17±6毫升/小时增加到饮水后第二小时的285±25毫升/小时。利尿的同时，尿激肽排泄量从23±9纳克/小时增加到94±17纳克/小时。尿激肽释放酶和尿钠排泄量保持不变。在七只狗中，通过胃内给予2%氯化钠，尿钠排泄量从0.87±0.22毫摩尔/小时增加到14.9±1.9毫摩尔/小时。尿量适度增加，从15.1±2.5毫升/小时增加到64.3±15.0毫升/小时。尿激肽排泄量未变。结果提示高尿量与尿激肽排泄之间存在关联。
