Teuscher A, Studer P P, Krebs A, Berger M, Aeberhard P
Schweiz Med Wochenschr. 1979 Sep 15;109(35):1273-80.
A 66-year-old male patient with non-insulin-dependent diabetes of probably 20 years' duration presented with necrolytic migratory erythema, stomatitis, anemia and weight loss. Plasma-glucagon concentration measured with Unger's antibody 30-K was 8500 pg/ml, representing a hundredfold elevation. Two thirds consisted of high molecular glucagon fractions (10 000--40 000 Dalton). This may be an important index for detection of glucagonoma with endocrine activity. After excision of the glucagonoma the clinical syndrome was reversed and the patient recovered completely. Histological and histochemical investigation confirmed that the tumor was a glucagonoma. Despite complete removal of the tumor and a normal plasma glucagon concentration, the diabetes remained unchanged. Excessive hyperglucagonemia does not appear to play a primary role in the pathogenesis of this patient's diabetes.
一名66岁男性患者，患有非胰岛素依赖型糖尿病，病程约20年，出现坏死性游走性红斑、口腔炎、贫血和体重减轻。用昂格尔30-K抗体测得的血浆胰高血糖素浓度为8500 pg/ml，升高了100倍。其中三分之二为高分子量胰高血糖素组分（10000 - 40000道尔顿）。这可能是检测具有内分泌活性的胰高血糖素瘤的重要指标。切除胰高血糖素瘤后，临床综合征得到逆转，患者完全康复。组织学和组织化学检查证实该肿瘤为胰高血糖素瘤。尽管肿瘤已完全切除且血浆胰高血糖素浓度正常，但糖尿病仍未改变。过高的高胰高血糖素血症似乎在该患者糖尿病的发病机制中不起主要作用。
