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[儿童颅内压的连续监测及神经重症监护的新进展]

[Continuous monitoring of intracranial pressure and new aspects of neurologic intensive care for children].

作者信息

Pfenninger J, Kaiser G

出版信息

Schweiz Med Wochenschr. 1979 Nov 17;109(44):1693-9.

PMID:524100
Abstract

A new concept of neurointensive care is presented which is based on earily measured parameters such as intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP) (CPP = MAP - ICP). ICP should preferably be measured by a subarachnoid hollow screw (Richmond screw). Of chief importance in neurointensive care (after adequate neurodiagnosis) is the avoidance or treatment of cerebral edema and maintenance of sufficient CPP, which should be above 50 mm Hg in older children. This is achieved by controlled hyperventilation under curare, generous oxygenation, control of body temperature, dexamethasone and possibly barbiturates in very high doses (phenobarbital and thiopentone). This kind of neurointensive care should be administered in all types of severe CNS accidents which are followed by substantial cerebral edema (head injuries, near drowning, Reye's syndrome, hypoxic encephalopathy, encephalitis, meningitis and intracranial bleeding). To obtain the indication for ICP monitoring, the depth of the disturbance of consciousness is measured by the Glasgow Coma Scale. Children with the aforementioned affections and a Glasgow Coma Scale below 6 to 8 should be treated as outlined above. The data published in the literature and our own experience point very much in this direction, especially for severe head injury, Reye's syndrome and near drowning.

摘要

提出了一种新的神经重症监护概念,该概念基于早期测量的参数,如颅内压(ICP)、平均动脉压(MAP)和脑灌注压(CPP)(CPP = MAP - ICP)。ICP最好通过蛛网膜下腔空心螺钉(里士满螺钉)进行测量。在神经重症监护中(在进行充分的神经诊断后),最重要的是避免或治疗脑水肿并维持足够的CPP,年龄较大的儿童CPP应高于50 mmHg。这可通过在箭毒作用下进行控制性过度通气、充分给氧、控制体温、使用地塞米松以及可能使用高剂量的巴比妥类药物(苯巴比妥和硫喷妥钠)来实现。这种神经重症监护应适用于所有类型的严重中枢神经系统意外事故,这些事故会继发严重脑水肿(头部损伤、近乎溺水、瑞氏综合征、缺氧性脑病、脑炎、脑膜炎和颅内出血)。为了获得ICP监测的指征,通过格拉斯哥昏迷量表来测量意识障碍的深度。患有上述疾病且格拉斯哥昏迷量表低于6至8分的儿童应按上述方法进行治疗。文献中发表的数据以及我们自己的经验都非常支持这一方向,尤其是对于严重头部损伤、瑞氏综合征和近乎溺水的情况。

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