含有吲哚-3-烷烃α-羟化酶的半人工细胞对小鼠进行低温诱导。
Induction of hypothermia in mice by semi-artificial cells containing indolyl-3-alkane alpha-hydroxylase.
作者信息
Schmer G, Roberts J
出版信息
Trans Am Soc Artif Intern Organs. 1979;25:39-44. doi: 10.1097/00002480-197902500-00008.
Abstract
The administration of red cell ghost encapsulated indolyl-3-alkane alpha-hydroxylase (an enzyme which destroys tryptophan by oxidation of the side chains) in CD-1 female mice causes effective tryptophan depletion in plasma and brain and induces hypothermia by probably decreasing the serotonin concentration in brain by decreasing the concentration of its precursor, L-tryptophan.
摘要
在CD-1雌性小鼠中给予红细胞血影包裹的吲哚-3-链烷α-羟化酶（一种通过侧链氧化破坏色氨酸的酶），会导致血浆和大脑中的色氨酸有效耗竭，并可能通过降低其前体L-色氨酸的浓度来降低大脑中的血清素浓度，从而诱发体温过低。
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