Isaeva E I, Platonova A L, Rovnova Z I, Kosiakov P N
Vopr Virusol. 1979 Nov-Dec(6):615-9.
The direct relationship between immunogenicity of H3N2 formolvaccine and neuraminidase activity was established. A single intranasal immunization of mice with the vaccine having a titer of hemagglutinin 1:20,000-1:40,000 in 0.5 ml with active neuraminidase increased the resistance of the animals to the challenge with mouse-adapted influenza A/USSR/053/74 (H3N2) virus almost 5-fold. A vaccine with the same hemagglutinin titer but with neuraminidase inactivated by physico-chemical factors or blocked by specific antibody exerted a protective effect 2.5-3 fold weaker than the vaccine with the active enzyme.
已确定H3N2福尔马林疫苗的免疫原性与神经氨酸酶活性之间的直接关系。用0.5毫升血凝素效价为1:20,000 - 1:40,000且具有活性神经氨酸酶的疫苗对小鼠进行单次鼻内免疫，可使动物对适应小鼠的甲型/苏联/053/74（H3N2）流感病毒攻击的抵抗力提高近5倍。血凝素效价相同但神经氨酸酶被物理化学因素灭活或被特异性抗体阻断的疫苗，其保护作用比具有活性酶的疫苗弱2.5 - 3倍。
