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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wheldrake J F, Hawke D, Baudinette R V

Xenobiotica. 1979 Sep;9(9):565-9. doi: 10.3109/00498257909042322.

The levels of enzymes associated with the hapatic mixed-function oxidase system, and the rates of oxidation of three substrates, are compared in the desert rodent, Notomys alexis, and the laboratory mouse, Mus musculus. 2. In general, the activity of the mixed-function oxidase system in Notomys alexis is greater than in Mus musculus. 3. Previous reports of the low rates of elimination of lipophilic compounds in the desert rodent are therefore not explicable by differences in metabolism. It is suggested that the lower rates of urine production is a more likely explanation. 4. The production of small volumes of concentrated urine is suggested to result in the longer retention of some foreign compounds.

对荒漠啮齿动物澳洲弹鼠和实验室小鼠小家鼠体内与肝脏混合功能氧化酶系统相关的酶水平以及三种底物的氧化速率进行了比较。2. 一般来说，澳洲弹鼠体内混合功能氧化酶系统的活性高于小家鼠。3. 因此，先前关于荒漠啮齿动物亲脂性化合物消除速率低的报道不能用代谢差异来解释。有人认为，较低的尿量生成速率更有可能是原因。4. 少量浓缩尿液的产生被认为会导致一些外来化合物的保留时间更长。

Wheldrake J F, Hawke D, Baudinette R V

Xenobiotica. 1979 Sep;9(9):565-9. doi: 10.3109/00498257909042322.

The levels of enzymes associated with the hapatic mixed-function oxidase system, and the rates of oxidation of three substrates, are compared in the desert rodent, Notomys alexis, and the laboratory mouse, Mus musculus. 2. In general, the activity of the mixed-function oxidase system in Notomys alexis is greater than in Mus musculus. 3. Previous reports of the low rates of elimination of lipophilic compounds in the desert rodent are therefore not explicable by differences in metabolism. It is suggested that the lower rates of urine production is a more likely explanation. 4. The production of small volumes of concentrated urine is suggested to result in the longer retention of some foreign compounds.

对荒漠啮齿动物澳洲弹鼠和实验室小鼠小家鼠体内与肝脏混合功能氧化酶系统相关的酶水平以及三种底物的氧化速率进行了比较。2. 一般来说，澳洲弹鼠体内混合功能氧化酶系统的活性高于小家鼠。3. 因此，先前关于荒漠啮齿动物亲脂性化合物消除速率低的报道不能用代谢差异来解释。有人认为，较低的尿量生成速率更有可能是原因。4. 少量浓缩尿液的产生被认为会导致一些外来化合物的保留时间更长。