Brus R, Szkilnik R, Jamrozik Z, Zabawska J
Acta Biol Med Ger. 1979;38(4):635-40.
Prostaglandin F2 alpha (PG F2 alpha) in doses of 1 and 10 micrograms applied intraventricularly causes a rise in body temperature and exerts a sedative action on rat behaviour. Chemical sympathectomy of the central nervous system (CNS) induced by a twofold intraventricular administration of 250 micrograms of 6-hydroxydopamine reduces the influence of PG F2 alpha on the body temperature and behaviour. Reserpine administered to rats with chemical sympathectomy of the central nervous system reverses or prevents the PG F2 alpha action on body temperature of the animals. The results of the experiments seem to indicate that the central monoaminergic mechanisms play a role in the central action of PG F2 alpha on body temperature and behaviour.
脑室内注射剂量为1微克和10微克的前列腺素F2α（PG F2α）会导致体温升高，并对大鼠行为产生镇静作用。通过脑室内两次注射250微克6-羟基多巴胺诱导的中枢神经系统（CNS）化学性交感神经切除术可降低PG F2α对体温和行为的影响。对进行中枢神经系统化学性交感神经切除术的大鼠给予利血平可逆转或阻止PG F2α对动物体温的作用。实验结果似乎表明，中枢单胺能机制在PG F2α对体温和行为的中枢作用中发挥作用。
