Stajić M, Milosavljević J, Begić-Janev A
Acta Hepatogastroenterol (Stuttg). 1979 Oct;26(5):375.
In the course of 4 years, among 11,738 admissions there were 245 (2.08%) patients with cholestasis (106 women and 139 men). Intrahepatic cholestasis (i.c.) was detected in 46.5%, and extrahepatic (e.c.) in 53.5%. The most frequent cause of i.c. were alcoholic and nonalcoholic chr. liver disease (fatty liver, chr. hepatitis, cirrhosis) (37% and 30%), acute viral hepatitis (15%) and toxic liver injury (14%) respectively. The causes of e.c. were: choledocholithiasis (44%), cancer of the pancreatic head (15%), cancer of gallbladder and extrahepatic ducts (12%) and cancer of liver (10%). The causes of c. were benigne, in 78.2%, while malignant neoplasms were present in 21.8%. Out of the multitude of laboratory tests two appeared particularly significant: glut, transpeptidase was pathologic in 81% of alcoholic liver disease, in 62% of the cases with obstructive jaundice and in 27.7% of malignant neoplasms. LX-lipoprotein examined in 52 patients was positive in 24% of i.c., and 60% of e.c. Proliferation of bile ducts was the most frequent finding in surgical liver biopsies in choledocholithiasis cases.
在4年期间，11738例住院患者中有245例（2.08%）患有胆汁淤积（106例女性和139例男性）。肝内胆汁淤积（i.c.）占46.5%，肝外胆汁淤积（e.c.）占53.5%。肝内胆汁淤积最常见的病因分别是酒精性和非酒精性慢性肝病（脂肪肝、慢性肝炎、肝硬化）（37%和30%）、急性病毒性肝炎（15%）和中毒性肝损伤（14%）。肝外胆汁淤积的病因有：胆总管结石（44%）、胰头癌（15%）、胆囊和肝外胆管癌（12%）以及肝癌（10%）。胆汁淤积的病因中，良性的占78.2%，恶性肿瘤占21.8%。在众多实验室检查中，有两项检查显得尤为重要：谷丙转氨酶在81%的酒精性肝病、62%的梗阻性黄疸病例和27.7%的恶性肿瘤中呈病理性升高。在52例患者中检测的LX - 脂蛋白在46.5%的肝内胆汁淤积病例和60%的肝外胆汁淤积病例中呈阳性。在胆总管结石病例的手术肝活检中，胆管增生是最常见的发现。
