Tkaczewski W, Chojnacki J, Bogoniowska Z
Acta Hepatogastroenterol (Stuttg). 1979 Oct;26(5):396-8.
The blood serum levels of gastrin and insulin and arterial blood levels of glucose were determined immediately before intravenous injection of 1 mg of glucagon, and 10, 20, 40 and 60 minutes later in 12 gastric ulcer patients, 14 duodenal ulcer patients and 12 controls using the radioimmunological and orthotoluidine methods respectively. Following glucagon administration the gastrin levels dropped in the controls and the gastrin patients, and increased in the duodenal patients by an average of 30%. Insulin levels increased in all three groups, but the increase was statistically significant in the two patients groups. Glucose levels in the blood also increased with no significant differences between the groups. It is suggested that the different effect of glucagon on gastrin levels may be due to gastrin-insulin interaction; the levels of the two hormones in the blood of duodenal patients were higher than in the other two groups studied.
分别采用放射免疫法和邻甲苯胺法，在12例胃溃疡患者、14例十二指肠溃疡患者和12例对照者静脉注射1毫克胰高血糖素之前以及之后10、20、40和60分钟，测定血清胃泌素和胰岛素水平以及动脉血葡萄糖水平。给予胰高血糖素后，对照组和胃溃疡患者的胃泌素水平下降，而十二指肠溃疡患者的胃泌素水平平均升高30%。三组的胰岛素水平均升高，但在两个患者组中升高具有统计学意义。血液中的葡萄糖水平也升高，各组之间无显著差异。提示胰高血糖素对胃泌素水平的不同影响可能归因于胃泌素 - 胰岛素相互作用；十二指肠溃疡患者血液中这两种激素的水平高于其他两组研究对象。
