Scanu A, Pollard H, Hirz R, Kothary K
Proc Natl Acad Sci U S A. 1969 Jan;62(1):171-8. doi: 10.1073/pnas.62.1.171.
When examined by circular dichroism and ultraviolet spectroscopy, human serum low-density lipoprotein (LDL) and its delipidated product, apo LDL, exhibited reversible thermal changes. The more marked temperature sensitivity of apo LDL as compared to LDL was taken to support a constraining role by lipids on the observed structural instability of the apoprotein.
通过圆二色性和紫外光谱检查时,人血清低密度脂蛋白(LDL)及其脱脂产物载脂蛋白LDL(apo LDL)表现出可逆的热变化。与LDL相比,apo LDL对温度更敏感,这被认为支持了脂质对所观察到的载脂蛋白结构不稳定性具有限制作用的观点。