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棉尘病可能的病原体对肺泡巨噬细胞鲁米诺依赖化学发光的抑制作用。

Inhibition of luminol-dependent chemiluminescence of alveolar macrophages by possible etiological agents of byssinosis.

作者信息

Greenblatt G A, Ziprin R L

出版信息

Am Ind Hyg Assoc J. 1979 Oct;40(10):860-5. doi: 10.1080/15298667991430406.

DOI:10.1080/15298667991430406
PMID:525611
Abstract

Aqueous extracts of cotton bracts inhibited luminol-dependent chemiluminescence of phagocytosing alveolar macrophages. The inhibitory compounds were partitioned into organic solvents. Chromotographic analysis indicated that these compounds were either lacinilene C or its 7-methyl ether and scopoletin. The fact that the inhibitory activity of these compounds was always less than that of the total extract suggests synergistic action. These compounds may function as etiological agents of byssinosis.

摘要

棉苞的水提取物抑制了吞噬性肺泡巨噬细胞的鲁米诺依赖性化学发光。抑制性化合物被分配到有机溶剂中。色谱分析表明,这些化合物要么是拉西尼烯C或其7-甲基醚,要么是东莨菪素。这些化合物的抑制活性总是低于总提取物的抑制活性,这一事实表明存在协同作用。这些化合物可能是棉尘病的病原体。

相似文献

1
Inhibition of luminol-dependent chemiluminescence of alveolar macrophages by possible etiological agents of byssinosis.棉尘病可能的病原体对肺泡巨噬细胞鲁米诺依赖化学发光的抑制作用。
Am Ind Hyg Assoc J. 1979 Oct;40(10):860-5. doi: 10.1080/15298667991430406.
2
Bovine alveolar macrophages. Phagocytic activation of luminol-dependent chemiluminescence in bovine pulmonary lavage cells.
Zentralbl Veterinarmed B. 1981;28(8):603-11.
3
The relevance of Lacinilene C7-methyl ether to byssinosis. Experience with natural product from bracts and synthetic chemical in leukocyte recruitment.拉西尼林C7 - 甲醚与棉尘肺的相关性。苞片天然产物和合成化学品在白细胞募集方面的研究经验。
Chest. 1981 Apr;79(4 Suppl):58S-61S.
4
Inhibition of alveolar macrophage spreading and phagocytosis by cotton bract tannin. A potential mechanism in the pathogenesis of byssinosis.棉苞叶单宁对肺泡巨噬细胞铺展和吞噬作用的抑制。棉尘肺发病机制中的一种潜在机制。
Am J Pathol. 1990 Aug;137(2):263-74.
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Analysis and comparison of the luminol-dependent chemiluminescence responses of alveolar macrophages and neutrophils.肺泡巨噬细胞和中性粒细胞的鲁米诺依赖性化学发光反应的分析与比较。
J Reticuloendothel Soc. 1980 Sep;28(3):275-83.
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The etiology of byssinosis--comparison of prostaglandin F2 alpha synthesis by alveolar macrophages stimulated with extracts from glanded and glandless cotton cultivars.棉尘病的病因——用有腺体和无腺体棉花品种提取物刺激肺泡巨噬细胞后前列腺素F2α合成的比较
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[Luminol-amplified chemiluminescence evaluation of the microbicidal property of alveolar macrophages in response to drugs].
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The etiology of byssinosis--possible role of prostaglandin F2alpha synthesis by alveolar macrophages.棉尘病的病因——肺泡巨噬细胞合成前列腺素F2α的可能作用。
Am Ind Hyg Assoc J. 1981 Jun;42(6):445-8. doi: 10.1080/15298668191420035.
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Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar and peritoneal macrophages.鲁米诺依赖的化学发光法检测兔肺泡巨噬细胞和腹腔巨噬细胞的吞噬活性
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引用本文的文献

1
Vegetable dust and airway disease: inflammatory mechanisms.蔬菜粉尘与气道疾病:炎症机制
Environ Health Perspect. 1986 Apr;66:7-15. doi: 10.1289/ehp.86667.
2
Relationship of byssinosis to the generation of oxygen radicals by bract tissues of cotton plants.棉尘病与棉花植株苞叶组织产生氧自由基的关系。
Mol Cell Biochem. 1989 Aug 15;89(1):15-9. doi: 10.1007/BF00228275.