关于循环淋巴细胞在针对不同抗原的初次抗体反应起始过程中作用的进一步研究。
Further studies on the role of circulating lymphocytes in the initiation of primary antibody responses to different antigens.
作者信息
Strober S, Law L W
出版信息
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1023-30. doi: 10.1073/pnas.62.4.1023.
Thoracic duct cells obtained from normal (unimmunized) donors restored the primary hemolysin response of lethally irradiated or neonatally thymectomized rats to sheep red blood cells. Synergy between thoracic duct cells and bone-marrow cells was demonstrated in the irradiated hosts. However, thoracic duct cells did not restore the primary antibody response of irradiated rats challenged with diphtheria toxoid, but did restore the response of neonatally thymectomized rats. The addition of peritoneal exudate cells or bone-marrow cells to inocula of thoracic duct cells also failed to restore the response of irradiated hosts to diphtheria toxoid, although normal spleen cells restored the response. These findings indicate that the cellular events involved in the initiation of the primary antibody response to sheep red blood cells differ from those involved in the response to diphtheria toxoid.
从正常（未免疫）供体获得的胸导管细胞恢复了经致死性照射或新生期胸腺切除的大鼠对绵羊红细胞的初次溶血素反应。在受照射的宿主体内证明了胸导管细胞与骨髓细胞之间的协同作用。然而，胸导管细胞不能恢复经照射的大鼠对白喉类毒素攻击的初次抗体反应，但能恢复新生期胸腺切除大鼠的反应。向胸导管细胞接种物中添加腹腔渗出细胞或骨髓细胞也未能恢复受照射宿主对白喉类毒素的反应，尽管正常脾细胞能恢复该反应。这些发现表明，对绵羊红细胞的初次抗体反应起始过程中涉及的细胞事件与对白喉类毒素反应中涉及的细胞事件不同。
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