Pohorecky L A, Zigmond M J, Heimer L, Wurtman R J
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1052-5. doi: 10.1073/pnas.62.4.1052.
Removal of one olfactory bulb causes marked changes in the norepinephrine contents of several brain regions. The brainstem catecholamine level is higher on the side of the lesion than on the control side, whereas telencephalic norepinephrine is lower ipsilateral to the lesion. The apparent decline in telencephalic norepinephrine is associated with a parallel decrease in the ability of this region to take up and retain (3)H-norepinephrine injected into the lateral cerebral ventricle. Within the ipsilateral olfactory tubercle, there is also a significant decrease in the activity of the enzyme phenylethanolamine-N-methyl transferase, which catalyzes the conversion of norepinephrine to epinephrine. The results of this study suggest that measurement of changes in the uptake of (3)H-norepinephrine injected into the cerebral ventricle can be used as a technique for mapping central adrenergic pathways.
切除一侧嗅球会导致几个脑区去甲肾上腺素含量发生显著变化。脑干儿茶酚胺水平在损伤侧高于对照侧，而端脑去甲肾上腺素在损伤同侧较低。端脑去甲肾上腺素的明显下降与该区域摄取和保留注入侧脑室的（3）H-去甲肾上腺素的能力平行下降有关。在同侧嗅结节内，催化去甲肾上腺素转化为肾上腺素的苯乙醇胺-N-甲基转移酶的活性也显著降低。本研究结果表明，测量注入脑室的（3）H-去甲肾上腺素摄取变化可作为绘制中枢肾上腺素能通路的一种技术。
