Gill M A, Kern J W
Am J Hosp Pharm. 1979 Dec;36(12):1704-6.
Gentamicin pharmacokinetics were studied in eight patients with ascites. Gentamicin serum levels were measured by radioimmunoassay immediately before, 15 minutes after, and at one and two estimated half-lives after intermittent i.v. infusions of gentamicin. Volumes of distributions (Vd) calculated for the eight patients were significantly larger than mean values reported for the drug in normal patients (p less than 0.025). Vd ranged from 20.2 to 53 liters and correlated poorly with lean and total body weights. In patients with ascites or abnormal extracellular fluid volumes, gentamicin dosage should be based on frequent measurements of serum gentamicin levels and on clinical response.
对8例腹水患者的庆大霉素药代动力学进行了研究。在间歇性静脉输注庆大霉素之前、之后15分钟以及估计的1个和2个半衰期时，通过放射免疫测定法测量庆大霉素血清水平。计算出的这8例患者的分布容积（Vd）显著大于正常患者中该药物报告的平均值（p小于0.025）。Vd范围为20.2至53升，与瘦体重和总体重的相关性较差。对于有腹水或细胞外液量异常的患者，庆大霉素的剂量应基于血清庆大霉素水平的频繁测量和临床反应。
