X射线和负π介子对小鼠肾脏的比较性晚期效应。

Jordan S W, Yuhas J M, Key C R, Hogstrom K R, Butler J L, Kligerman M M

Am J Pathol. 1979 Nov;97(2):315-26.

A system is described for comparing various modalities and fractionation schedules of radiation by means of their long-term morphologic effects upon the mouse kidney. The comparison system utilizes a grading scale for histopathologic changes in which a given histologic grade depends upon meeting defined threshold criteria, rather than quantitation of a particular measurement. Renal tubular alterations served as the basis for comparison, since they appeared more reliably defined than glomerular changes. The radiation dose that induced a specific threshold effect in kidneys from 50% of the animals at 6 months was defined as the effective dose-50%, or ED50.ED50 was found for x-rays and negative pimesons administered in 1, 2, or 5 fractions. From these data, the relative biologic effectiveness (RBE) of negative pi-mesons with respect to x-rays was determined for each fractionation schedule.

本文描述了一种系统，该系统通过辐射对小鼠肾脏的长期形态学影响来比较各种辐射方式和分割方案。该比较系统利用了组织病理学变化的分级量表，其中给定的组织学等级取决于是否满足定义的阈值标准，而不是特定测量的定量。肾小管改变作为比较的基础，因为它们看起来比肾小球变化更明确。在6个月时能使50%的动物肾脏产生特定阈值效应的辐射剂量被定义为有效剂量50%，即ED50。分别求出了以1、2或5次分割给予X射线和负π介子的ED50。根据这些数据，确定了每种分割方案下负π介子相对于X射线的相对生物效应（RBE）。