Farcot J M, Haberer J P, Laugner B, Schoeffler P, Farny J, Gauthier-Lafaye P
Anesth Analg (Paris). 1979;36(7-8):323-9.
Pain due to bone metastasis in hormonodependent cancer (of the breast or the prostates more particularly) can be relieved by surgery directed at the endocrinic system. The most efficient techniques are hypophysectomies and hypophysiolysis (or neuroadenolysis). The intrasellar injection of alcohol through the transnasal-transsphenoidal route is a fairly simple procedure which can be carried out on such fragile patients without too much risk. The authors here report the first results obtained with this procedure in 12 pateints. Full sedation of pain is achieved in 30 to 40 p. cent of the cases. The duration of analgesia varies and pain frequently returns. One of the advantages of this procedure lies in the fact that such an injection may be repeated if necessary. The intrasellar injection of alcohol is but one of the many techniques available to practitioners working in the field of intractable pain.
激素依赖性癌症(尤其是乳腺癌或前列腺癌)骨转移引起的疼痛可通过针对内分泌系统的手术缓解。最有效的技术是垂体切除术和垂体破坏术(或神经垂体溶解术)。经鼻-经蝶窦途径在蝶鞍内注射酒精是一种相当简单的操作,对于这类身体虚弱的患者来说实施风险不大。本文作者报告了该操作在12例患者中取得的初步结果。30%至40%的病例实现了疼痛的完全缓解。镇痛持续时间各不相同,疼痛经常复发。该操作的优点之一在于如有必要,这种注射可以重复进行。蝶鞍内注射酒精只是从事顽固性疼痛治疗领域的医生可采用的众多技术之一。