Cutlip R C, Jackson T A, Lehmkuhl H D
Am J Vet Res. 1979 Oct;40(10):1370-4.
Lesions in sheep with ovine progressive pneumonia are described. Lungs were mottled grayish-pink, firm, and large (two to three times normal weight). There was chronic diffuse interstitial pneumonitis characterized by extensive hyperplasia of lymphoid cells around airways and blood vessels and by accumulation of mononuclear cells in the interstitium. In some lungs, this reaction was accompanied by excessive fibrous tissue and smooth muscle and less frequently by hyperplastic epithelium of terminal bronchioles and alveoli. Secondary bronchopneumonia was common. Lymphocytic meningitis, choroiditis, and leukoencephalitis were seen in a few sheep. Meninges and choroid plexuses were infiltrated with lymphoid cells, and subependymal blood vessels were cuffed with lymphoid cells. Much subependymal white matter was demyelinated and had foci of necrosis and gliosis.
描述了患有绵羊进行性肺炎的绵羊的病变情况。肺脏呈斑驳的灰粉色，质地坚实且体积增大（重量为正常的两到三倍）。存在慢性弥漫性间质性肺炎，其特征为气道和血管周围淋巴细胞广泛增生以及间质中单核细胞积聚。在一些肺脏中，这种反应伴有过多的纤维组织和平滑肌，较少伴有终末细支气管和肺泡的上皮增生。继发性支气管肺炎很常见。在少数绵羊中可见淋巴细胞性脑膜炎、脉络膜炎和脑白质炎。脑膜和脉络丛有淋巴细胞浸润，室管膜下血管被淋巴细胞包绕。大量室管膜下白质脱髓鞘，并有坏死灶和胶质细胞增生。
