Appleton J A, DeBuysscher E V, Kadis S
Am J Vet Res. 1979 Dec;40(12):1757-61.
The immune defense system of the kidney was studied by inducing ascending pyelonephritis in rats with Corynebacterium renale. With the fluorescent antibody technique, C renale organisms were observed in the renal pelvis, but were not coated with antibody until they reached the medulla. Histopathologic evaluation of renal tissues collected serially after inoculation confirmed the presence of infection in the medulla when antibody coating occurred. Serum anti-C renale antibody concentrations increased after antibody-coated bacteria appeared in the urine and kidney. Free anti-C renale antibody was not detected in urine from infected rats, using the microagglutination assay. Antibody coating appears to occur only after C renale organisms invade the medulla during ascending pyelonephritis.
通过用肾棒状杆菌诱导大鼠上行性肾盂肾炎，对肾脏的免疫防御系统进行了研究。采用荧光抗体技术，在肾盂中观察到肾棒状杆菌，但直到它们到达髓质才被抗体包被。接种后连续收集的肾组织的组织病理学评估证实，当出现抗体包被时，髓质中存在感染。在尿液和肾脏中出现抗体包被的细菌后，血清抗肾棒状杆菌抗体浓度升高。使用微量凝集试验，在感染大鼠的尿液中未检测到游离的抗肾棒状杆菌抗体。抗体包被似乎仅在肾棒状杆菌在上行性肾盂肾炎期间侵入髓质后才会发生。
