大脑中的雌激素“受体”：一个未解决的问题。
Estrogen "receptors" in brain: an unsolved problem.
作者信息
Whalen R E, Maurer R A
出版信息
Proc Natl Acad Sci U S A. 1969 Jul;63(3):681-5. doi: 10.1073/pnas.63.3.681.
Various investigators have postulated that estrogen-sensitive structures contain "receptors" which accumulate and bind estradiol. Further, it has been implied that brain receptors function in a similar way to uterine receptors, even though the evidence for this conclusion is not strong. The present study was designed to compare the accumulation of radioactivity by brain and uterus following (3)H-estradiol treatment in estrous, diestrous, and ovariectomized rats. Uterus exhibited high levels of radioactivity in diestrus, but not in estrus or the ovariectomized condition. The accumulation of hormone by brain did not fluctuate with the various levels of endogenous hormone stimulation, but rather showed a pattern of uptake similar to muscle, a nontarget tissue. It was concluded that if brain hormone receptors exist, they do not respond to estradiol as do uterine receptors.
许多研究者推测，雌激素敏感结构含有能聚集并结合雌二醇的“受体”。此外，有人暗示脑受体的功能与子宫受体类似，尽管这一结论的证据并不充分。本研究旨在比较动情期、动情间期和去卵巢大鼠经（3）H-雌二醇处理后，脑和子宫对放射性的聚集情况。子宫在动情间期表现出高水平的放射性，但在动情期或去卵巢状态下则没有。脑对激素的聚集并不随内源性激素刺激水平的变化而波动，而是呈现出与非靶组织肌肉相似的摄取模式。得出的结论是，如果脑激素受体存在，它们对雌二醇的反应与子宫受体不同。
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