原黄素诱变机制。
Mechanism of proflavin mutagenesis.
作者信息
Sarabhai A, Lamfrom H
出版信息
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1196-7. doi: 10.1073/pnas.63.4.1196.
Abstract
The mutagenic action of proflavin on bacteriophage T4 is greater in the presence of defective T4 ligase than in the presence of normal T4 ligase. This suggests that the persistence of single-strand breaks in DNA enhances proflavin mutagenesis.
摘要
在存在缺陷型T4连接酶的情况下，原黄素对噬菌体T4的诱变作用比存在正常T4连接酶时更强。这表明DNA中单链断裂的持续存在会增强原黄素诱变作用。
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本文引用的文献
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A frame-shift mutation involving the addition of two base pairs in the lysozyme gene of phage t4.一种移码突变，涉及噬菌体T4溶菌酶基因中两个碱基对的添加。
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1692-8. doi: 10.1073/pnas.56.6.1692.
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The structure of the DNA-acridine complex.DNA-吖啶复合物的结构。
Proc Natl Acad Sci U S A. 1963 Jan 15;49(1):94-102. doi: 10.1073/pnas.49.1.94.
3
General nature of the genetic code for proteins.蛋白质遗传密码的一般性质。
Nature. 1961 Dec 30;192:1227-32. doi: 10.1038/1921227a0.
4
Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4.脱氧核糖核酸的酶促断裂与连接。II. 噬菌体T4中多核苷酸连接酶的结构基因
Proc Natl Acad Sci U S A. 1967 Aug;58(2):665-72. doi: 10.1073/pnas.58.2.665.
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Change of a sequence of amino acids in phage T4 lysozyme by acridine-induced mutations.吖啶诱导的突变导致噬菌体T4溶菌酶中氨基酸序列的改变。
Proc Natl Acad Sci U S A. 1966 Aug;56(2):500-7. doi: 10.1073/pnas.56.2.500.
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