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急性淋巴细胞白血病中使用阿糖胞苷和L-天冬酰胺酶进行缓解诱导

Remission induction with cytosine arabinoside and L-asparaginase in acute lymphoblastic leukaemia.

作者信息

McElwain T J, Hardisty R M

出版信息

Br Med J. 1969 Dec 6;4(5683):596-8. doi: 10.1136/bmj.4.5683.596.

DOI:10.1136/bmj.4.5683.596
PMID:5261071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1630069/
Abstract

Nine patients with acute lymphoblastic leukaemia in relapse were treated with a course of cytosine arabinoside followed immediately by a course of L-asparaginase. Eight patients achieved complete remission of their disease. This combination of drugs is sufficiently effective to suggest that further trial is needed. It is possible that the combination has a synergistic effect.

摘要

9例急性淋巴细胞白血病复发患者接受了一个疗程的阿糖胞苷治疗，随后立即接受一个疗程的L-天冬酰胺酶治疗。8例患者疾病完全缓解。这种药物组合疗效显著，表明有必要进一步试验。该组合可能具有协同作用。

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Remission induction with cytosine arabinoside and L-asparaginase in acute lymphoblastic leukaemia.急性淋巴细胞白血病中使用阿糖胞苷和L-天冬酰胺酶进行缓解诱导
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[Sequential combination of high-dose cytosine arabinoside and L-asparaginase in the treatment of refractory acute leukemia and malignant lymphoma].
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引用本文的文献

1
Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.成人急性淋巴细胞白血病诱导治疗期间L-天冬酰胺酶的多种严重毒性及其创新管理
Case Rep Hematol. 2019 Nov 20;2019:9086570. doi: 10.1155/2019/9086570. eCollection 2019.
2
L-asparaginase in treatment of acute leukaemia and lymphosarcoma.L-天冬酰胺酶治疗急性白血病和淋巴肉瘤。
Br Med J. 1970 Jan 24;1(5690):191-5. doi: 10.1136/bmj.1.5690.191.

本文引用的文献

1
ACTION OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE ON THE NUCLEIC ACID METABOLISM AND VIABILITY OF HELA CELLS.1-β-D-阿拉伯呋喃糖基胞嘧啶对海拉细胞核酸代谢及生存能力的作用
Cancer Res. 1965 Jun;25:698-702.
2
Drug effect in acute leukemia.药物在急性白血病中的作用。
J Clin Invest. 1969 Jun;48(6):1124-30. doi: 10.1172/JCI106069.
3
Arabinosyl cytosine: a useful agent in the treatment of acute leukemia in adults.阿糖胞苷：治疗成人急性白血病的有效药物。
Blood. 1968 Oct;32(4):507-23.