Kwaan H C
Artery. 1979 Mar;5(3):285-90.
According to the thrombogenetic (encrustation) theory of atherogenesis first postulated by Rokitansky, accretions of blood components including fibrin and platelets may be the initial event. Since fibrinolysis has a profound influence on the resolution of fibrin deposits, the role of fibrinolysis in atherogenesis is discussed. Evidences supporting this role include the demonstration of inhibitors of fibrinolysis, decreased circulating fibrinolytic activity in patients who are atherosclerotic, and inhibition of circulating fibrinolytic activity by several atherosclerosis-risk factors such as increasing age, cigarette smoking, hypercholesterolemia, hypertriglyceridemia and diabetes mellitus. It is concluded that a combination of systemic inhibitions of fibrinolysis over a long-term period and a local vascular injury, play a decided role in atherogenesis.
根据罗基坦斯基首次提出的动脉粥样硬化血栓形成（结痂）理论，包括纤维蛋白和血小板在内的血液成分的积聚可能是初始事件。由于纤维蛋白溶解对纤维蛋白沉积物的溶解有深远影响，因此讨论了纤维蛋白溶解在动脉粥样硬化形成中的作用。支持这一作用的证据包括纤维蛋白溶解抑制剂的证明、动脉粥样硬化患者循环纤维蛋白溶解活性降低，以及年龄增长、吸烟、高胆固醇血症、高甘油三酯血症和糖尿病等几种动脉粥样硬化危险因素对循环纤维蛋白溶解活性的抑制。得出的结论是，长期全身性纤维蛋白溶解抑制与局部血管损伤相结合，在动脉粥样硬化形成中起决定性作用。
