Stepanova R N, Khkimova S Kh, Strochkova L S
Arkh Anat Gistol Embriol. 1979 Dec;77(12):52-8.
Endometrium obtained during menses from 46 healthy women in reproductive age was investigated morphologically and cytospectrophotometrically in order to solve the problem on the source of the cells reepithelizing the uterine mucous membrane after desquamation. It was stated that desquamation takes place not in the whole functional layer of endometrium, some mucous fragments, covered with persisting luminal epithelium, are always preserved. During endometrial regeneration the cells of the luminal and glandular epithelia and those of endometrial stroma are predominantly diploid. The amount of premitotic cells in population is so small that they cannot secure any intensive cellular proliferation. Mitogenesis in endometrium is stimulated only after a complete restoration of the epithelial layer. It is suggested that persisting luminal epithelium is the source of cells for reepithelization; they migrate towards endometrial "wounds" and repair defects in the uterine mucosa during the regeneration phase.
为了解决子宫内膜脱落后子宫黏膜重新上皮化的细胞来源问题，对46名育龄健康女性月经期间获取的子宫内膜进行了形态学和细胞分光光度法研究。结果表明，子宫内膜的脱落并非发生在整个功能层，总有一些覆盖着持续存在的腔上皮的黏液碎片得以保留。在子宫内膜再生过程中，腔上皮和腺上皮细胞以及子宫内膜基质细胞主要是二倍体。群体中前期细胞的数量极少，无法保证任何强烈的细胞增殖。只有在上皮层完全恢复后，子宫内膜的有丝分裂才会受到刺激。研究表明，持续存在的腔上皮是重新上皮化细胞的来源；它们在再生阶段向子宫内膜“伤口”迁移并修复子宫黏膜的缺损。
