• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脑去甲肾上腺素：猫脑干横断后假怒行为中神经元释放至关重要的证据。

Brain norepinephrine: evidence that neuronal release is essential for sham rage behavior following brainstem transection in cat.

作者信息

Reis D J, Fuxe K

出版信息

Proc Natl Acad Sci U S A. 1969 Sep;64(1):108-12. doi: 10.1073/pnas.64.1.108.

DOI:10.1073/pnas.64.1.108
PMID:5262991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC286133/
Abstract

There is a direct relationship between the magnitude of sham rage produced by brainstem transection in cat and the decrease of brainstem norepinephrine. The attacks of rage are augmented by protriptyline and inhibited by haloperidol, drugs respectively facilitating or depressing the action of norepinephrine centrally. Release of norepinephrine by brainstem neurons appears essential for appearance of this behavior.

摘要

猫脑干横断所产生的假怒程度与脑干去甲肾上腺素的减少之间存在直接关系。丙咪嗪可增强愤怒发作，氟哌啶醇则可抑制愤怒发作，这两种药物分别在中枢促进或抑制去甲肾上腺素的作用。脑干神经元释放去甲肾上腺素似乎是这种行为出现的必要条件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf2/286133/43433f791357/pnas00111-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf2/286133/43433f791357/pnas00111-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf2/286133/43433f791357/pnas00111-0122-a.jpg

相似文献

1
Brain norepinephrine: evidence that neuronal release is essential for sham rage behavior following brainstem transection in cat.脑去甲肾上腺素：猫脑干横断后假怒行为中神经元释放至关重要的证据。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):108-12. doi: 10.1073/pnas.64.1.108.
2
Depletion of noradrenaline in brainstem neurons during sham rage behaviour produced by acute brainstem transection in cat.猫急性脑干横断所致假怒行为期间脑干神经元中去甲肾上腺素的耗竭。
Brain Res. 1968 Mar;7(3):448-51. doi: 10.1016/0006-8993(68)90010-3.
3
Evidence that brain noradrenalin release in essential for sham rage behavior produced by acute brainstem transection in cat.有证据表明，大脑去甲肾上腺素的释放对于猫急性脑干横断所产生的假怒行为至关重要。
Trans Am Neurol Assoc. 1968;93:268-70.
4
Brain catecholamines: relation to defense reaction evoked by acute brainstem transection in cat.脑儿茶酚胺：与猫急性脑干横断诱发的防御反应的关系。
Science. 1967 Jun 30;156(3783):1768-70. doi: 10.1126/science.156.3783.1768.
5
Organization of brainstem noradrenaline hyperinnervation following neonatal 6-hydroxydopamine treatment in rat.新生大鼠经6-羟基多巴胺治疗后脑干去甲肾上腺素超神经支配的组织学研究
Anat Embryol (Berl). 1980;158(2):133-50. doi: 10.1007/BF00315901.
6
[Effect of progesterone on noradrenaline metabolism in the brain of ovariectomized rats].[孕酮对去卵巢大鼠脑内去甲肾上腺素代谢的影响]
Arzneimittelforschung. 1970 Jul;20(7):906-8.
7
Failure of dopamine to accumulate in central noradrenaline neurons after depletion with diethyldithiocarbamate.用二乙基二硫代氨基甲酸盐耗竭后，多巴胺在中枢去甲肾上腺素能神经元中蓄积失败。
J Pharm Pharmacol. 1967 Jul;19(7):481-3. doi: 10.1111/j.2042-7158.1967.tb08116.x.
8
[Effect of stimulants of the central nervous system on the motor activity of rats and the noradrenaline content in the brain stem].[中枢神经系统兴奋剂对大鼠运动活动及脑干去甲肾上腺素含量的影响]
Farmakol Toksikol. 1967 Sep-Oct;30(5):535-9.
9
Peculiarities in the changes of catecholamine level in the brain, blood, and adrenals of dogs and rats in ontogenesis.犬和大鼠个体发育过程中脑、血液及肾上腺中儿茶酚胺水平变化的特点
Dev Psychobiol. 1976 Mar;9(2):149-55. doi: 10.1002/dev.420090207.
10
Effect of 6-hydroxydopamine on agonistic behaviour elicited by stimulation of the hypothalamus in the cat.6-羟基多巴胺对猫下丘脑刺激引发的攻击行为的影响。
Med Biol. 1974 Dec;52(6):406-14.

引用本文的文献

1
Human threat circuits: Threats of pain, aggressive conspecific, and predator elicit distinct BOLD activations in the amygdala and hypothalamus.人类威胁回路：疼痛、同种攻击和捕食者的威胁在杏仁核和下丘脑引发不同的脑血流动力学激活。
Front Psychiatry. 2023 Jan 9;13:1063238. doi: 10.3389/fpsyt.2022.1063238. eCollection 2022.
2
The ecology of human fear: survival optimization and the nervous system.人类恐惧的生态学：生存优化与神经系统
Front Neurosci. 2015 Mar 18;9:55. doi: 10.3389/fnins.2015.00055. eCollection 2015.
3
Stimulation-induced behavioral inhibition: a new model for understanding physical violence.

本文引用的文献

1
Brain Catecholamines: Relation to the Defense Reaction Evoked by Amygdaloid Stimulation in Cat.脑儿茶酚胺：与猫杏仁核刺激诱发的防御反应的关系
Science. 1965 Jul 23;149(3682):450-1. doi: 10.1126/science.149.3682.450.
2
The inhibitory action of noradrenaline and other monoamines on spinal neurones.去甲肾上腺素及其他单胺对脊髓神经元的抑制作用。
J Physiol. 1966 Jul;185(2):298-322. doi: 10.1113/jphysiol.1966.sp007988.
3
EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.
刺激诱发的行为抑制：一种理解身体暴力的新模型。
Integr Physiol Behav Sci. 1999 Jul-Sep;34(3):177-97. doi: 10.1007/BF02688683.
4
Rubidium-induced increase in shock-elicited aggression in rats.铷诱导大鼠休克引发的攻击性增加。
Psychopharmacologia. 1971;22(3):250-60. doi: 10.1007/BF00401787.
5
Specific antagonism by dopamine inhibitors of items of amphetamine induced aggressive behaviour.多巴胺抑制剂对苯丙胺诱导的攻击行为的特异性拮抗作用。
Psychopharmacologia. 1972;24(4):485-95. doi: 10.1007/BF00423439.
6
Increased irritability: a permanent behavior change induced in the rat by intraventricular administration of 6-hydroxydopamine.易怒增加：通过脑室内注射6-羟基多巴胺在大鼠中诱导的永久性行为改变。
Psychopharmacologia. 1972;24(3):359-72. doi: 10.1007/BF00402530.
7
Nonlinear changes in activity and emotional reactivity scores following central noradrenergic lesions in rats.大鼠中枢去甲肾上腺素能损伤后活动及情绪反应评分的非线性变化
Psychopharmacologia. 1973 Oct 15;32(4):313-25. doi: 10.1007/BF00429467.
8
Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.大鼠脑单胺能神经元中的糖皮质激素受体免疫反应性
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9779-83. doi: 10.1073/pnas.83.24.9779.
9
Effect of a new benzodiazepine bromazepam on locomotor performance and brain monoamine metabolism.新型苯二氮䓬类药物溴西泮对运动能力和脑单胺代谢的影响。
J Neural Transm. 1978;42(4):251-61. doi: 10.1007/BF01673550.
中枢神经系统中单胺能神经元存在的证据。IV. 中枢神经系统中单胺能神经末梢的分布。
Acta Physiol Scand Suppl. 1965:SUPPL 247:37+.
4
PRESSOCEPTIVE AND CHEMOCEPTIVE AORTIC REFLEXES IN DECORTICATE AND IN DECEREBRATE CATS.去皮质和去大脑猫的压力感受性和化学感受性主动脉反射
Am J Physiol. 1965 Apr;208:708-14. doi: 10.1152/ajplegacy.1965.208.4.708.
5
DEPLETION OF THE AMINE STORES IN BRAIN CATECHOLAMINE TERMINALS ON AMYGDALOID STIMULATION.杏仁核刺激对脑儿茶酚胺终末中胺储备的消耗
Acta Physiol Scand. 1964 Dec;62:493-4. doi: 10.1111/j.1748-1716.1964.tb10450.x.
6
EXCITATION AND INHIBITION OF SHAM RAGE BEHAVIOR BY LOWER BRAIN STEM STIMULATION.低位脑干刺激对假怒行为的兴奋和抑制作用
Arch Ital Biol. 1963 Oct 5;101:614-31.
7
Improved technique for the fluorimetric estimation of catecholamines.儿茶酚胺荧光测定的改进技术。
Acta Physiol Scand. 1961 Apr;51:348-55. doi: 10.1111/j.1748-1716.1961.tb02128.x.
8
The inhibitory action of monoamines on lateral geniculate neurones.单胺对外侧膝状体神经元的抑制作用。
J Physiol. 1967 Jun;190(3):563-81. doi: 10.1113/jphysiol.1967.sp008228.
9
Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.关于丙咪嗪类药物和（+）-苯丙胺对中枢和外周儿茶酚胺能神经元作用的生化与组织化学研究。
Acta Physiol Scand. 1966 Jul-Aug;67(3):481-97. doi: 10.1111/j.1748-1716.1966.tb03334.x.
10
Responses of spinal cord interneurons to acetylcholine, norepinephrine and serotonin administered by microelectrophoresis.脊髓中间神经元对通过微电泳施加的乙酰胆碱、去甲肾上腺素和5-羟色胺的反应。
J Pharmacol Exp Ther. 1966 Sep;153(3):420-7.