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大鼠肝脏中的有机阴离子结合蛋白：药物诱导及其生理后果。

Organic anion-binding protein in rat liver: drug induction and its physiologic consequence.

作者信息

Reyes H, Levi A J, Gatmaitan Z, Arias I M

出版信息

Proc Natl Acad Sci U S A. 1969 Sep;64(1):168-70. doi: 10.1073/pnas.64.1.168.

DOI:10.1073/pnas.64.1.168
PMID:5262999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC286142/
Abstract

The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.

摘要

给大鼠服用苯巴比妥可增强肝脏对有机阴离子溴磺酞的体内摄取，同时增加肝脏细胞质有机阴离子结合蛋白Y的含量。本研究支持以下假设：Y是肝脏从血浆中选择性摄取某些有机阴离子的主要决定因素。Y的诱导可能有助于增强苯巴比妥和其他药物所引起的各种有机阴离子（药物、激素等）的肝脏摄取和代谢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e4/286142/0d66a0d39e6f/pnas00111-0182-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e4/286142/5146eb74e210/pnas00111-0182-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e4/286142/0d66a0d39e6f/pnas00111-0182-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e4/286142/5146eb74e210/pnas00111-0182-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10e4/286142/0d66a0d39e6f/pnas00111-0182-b.jpg

相似文献

1
Organic anion-binding protein in rat liver: drug induction and its physiologic consequence.大鼠肝脏中的有机阴离子结合蛋白：药物诱导及其生理后果。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):168-70. doi: 10.1073/pnas.64.1.168.
2
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis.对两种肝脏细胞质有机阴离子结合蛋白Y和Z的研究：药物、化学物质、激素及胆汁淤积的影响
J Clin Invest. 1971 Nov;50(11):2242-52. doi: 10.1172/JCI106721.
3
Structural and functional studies of ligandin, a major renal organic anion-binding protein.配体结合蛋白（一种主要的肾脏有机阴离子结合蛋白）的结构与功能研究
J Clin Invest. 1975 May;55(5):1009-19. doi: 10.1172/JCI108001.
4
Studies on the relationship of hepatic anion-binding proteins and sulfobromophthalein-glutathione conjugation in normal and phenobarbital-treated rats.正常及苯巴比妥处理大鼠肝脏阴离子结合蛋白与磺溴酞-谷胱甘肽结合反应关系的研究
Biochim Biophys Acta. 1975 Apr 7;385(2):334-42. doi: 10.1016/0304-4165(75)90361-x.
5
Immunological studies of Y protein. A major cytoplasmic organic anion-binding protein in rat liver.Y蛋白的免疫学研究。大鼠肝脏中的一种主要细胞质有机阴离子结合蛋白。
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6
Influence of drugs and chemicals upon hepatic enzymes and proteins. II. The effects of various barbiturates on the induction and reduction of hepatic cytoplasmic organic anion-binding proteins.药物和化学物质对肝酶及蛋白质的影响。II. 各种巴比妥类药物对肝细胞质有机阴离子结合蛋白诱导和减少的影响。
Gastroenterol Jpn. 1976;11(1):23-30. doi: 10.1007/BF02775447.
7
Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions.两种肝细胞质蛋白组分Y和Z及其在肝脏摄取胆红素、磺溴酞钠和其他阴离子中的可能作用。
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Hepatic microsomal induction and hepatic transport.肝微粒体诱导与肝脏转运。
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9
Phenobarbital specifically increases the hepatocellular uptake of sulfobromophthalein-glutathione.苯巴比妥可特异性增加肝细胞对磺溴酞谷胱甘肽的摄取。
Biochem Biophys Res Commun. 1987 Dec 31;149(3):921-6. doi: 10.1016/0006-291x(87)90496-7.
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Effect of fasting on hepatic ligandin, Z protein, and organic anion transfer from plasma in rats.禁食对大鼠肝脏配体蛋白、Z蛋白及血浆中有机阴离子转运的影响。
Am J Physiol. 1976 Nov;231(5 Pt. 1):1371-6. doi: 10.1152/ajplegacy.1976.231.5.1371.

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本文引用的文献

1
Effect of phenobarbital on the excretion of an exogenous bilirubin load.苯巴比妥对外源性胆红素负荷排泄的影响。
Biochem Pharmacol. 1967 May;16(5):827-35. doi: 10.1016/0006-2952(67)90055-x.
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Estimation of the turnover rate of barbiturate sidechain oxidation enzyme in rat liver.大鼠肝脏中巴比妥酸盐侧链氧化酶周转率的估计。
Mol Pharmacol. 1967 Mar;3(2):216-8.
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Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital.苯巴比妥明显诱导酶活性，致使一名高胆红素血症婴儿的葡萄糖醛酸结合能力增强。
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Is ligandin relevant for the uptake and storage of phallotoxins in liver cells?谷胱甘肽S-转移酶是否与肝细胞中毒伞毒素的摄取和储存有关？
Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):364-7. doi: 10.1007/BF00501320.
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Phenobarbital-digitoxin interaction in the guinea pig liver.苯巴比妥与洋地黄毒苷在豚鼠肝脏中的相互作用。
Eur J Drug Metab Pharmacokinet. 1982;7(3):165-71. doi: 10.1007/BF03189562.
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Ligandin: an adventure in liverland.配体蛋白：肝脏领域的一次探索。
Mol Cell Biochem. 1980 Feb 8;29(2):71-80. doi: 10.1007/BF00220301.
7
[Studies on hepatic storage capacity and maximum transport of sulfobromophthalein in chronic kidney failure].[慢性肾衰竭时磺溴酞钠肝内贮存量及最大转运量的研究]
Klin Wochenschr. 1971 Dec 15;49(24):1318-22. doi: 10.1007/BF01495518.
8
Bilirubin excretion in rats with normal and impaired bilirubin conjugation: effect of phenobarbital.正常及胆红素结合功能受损大鼠的胆红素排泄：苯巴比妥的作用
J Clin Invest. 1971 Dec;50(12):2606-13. doi: 10.1172/JCI106761.
9
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis.对两种肝脏细胞质有机阴离子结合蛋白Y和Z的研究：药物、化学物质、激素及胆汁淤积的影响
J Clin Invest. 1971 Nov;50(11):2242-52. doi: 10.1172/JCI106721.
10
Sites of competition in the selective hepatic uptake of rifamycin-SV, flavaspidic acid, bilirubin, and bromsulphthalein.利福霉素-SV、黄绵马酸、胆红素和溴磺酞在肝脏选择性摄取过程中的竞争位点。
Gut. 1974 Mar;15(3):220-6. doi: 10.1136/gut.15.3.220.
N Engl J Med. 1966 Dec 29;275(26):1461-6. doi: 10.1056/NEJM196612292752602.
4
Effect of bunamiodyl on hepatic uptake of sulfobromophthalein in the rat.布纳米地尔对大鼠肝脏摄取磺溴酞的影响。
Am J Physiol. 1966 Aug;211(2):395-9. doi: 10.1152/ajplegacy.1966.211.2.395.
5
Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus.苯巴比妥钠对一名患有先天性、非溶血性、非结合性高胆红素血症及核黄疸婴儿胆红素代谢的影响。
J Clin Invest. 1969 Jan;48(1):42-55. doi: 10.1172/JCI105973.
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Pharmacological implications of microsomal enzyme induction.微粒体酶诱导的药理学意义。
Pharmacol Rev. 1967 Sep;19(3):317-66.
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Influence of turnover rates on the responses of enzymes to cortisone.周转率对酶对可的松反应的影响。
Mol Pharmacol. 1965 Sep;1(2):149-56.
8
Deficiency of hepatic organic anion-binding protein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn.肝脏有机阴离子结合蛋白缺乏作为新生儿非溶血性未结合胆红素血症的可能病因
Lancet. 1969 Jul 19;2(7612):139-40. doi: 10.1016/s0140-6736(69)92444-1.
9
Decrease of total serum-bilirubin concentration in newborn infants after phenobarbitone treatment.苯巴比妥治疗后新生儿血清总胆红素浓度降低。
Lancet. 1968 Sep 28;2(7570):705-8. doi: 10.1016/s0140-6736(68)90750-2.