Borghi M, Olivetti G, Pecchini F
Ateneo Parmense Acta Biomed. 1979;50(2-3):165-71.
The Authors describe one case of acute renal insufficiency in a patient treated with high doses of gentamicin over a period of three weeks. The documentation includes electron microscope observations of needle biopsy material revealing the presence of electron-dense masses (cytosegregosomes) in the epithelial cells of the proximal renal tubules, such as had previously been described only in animal experiments and human autopsy studies. The clinical course and favorable outcome of this case of gentamicin-induced renal failuse afford the opportunity for some interesting considerations concerning the kinetics and toxic proclivities of this aminoglycoside antibiotic.
作者描述了1例在3周内接受大剂量庆大霉素治疗的患者发生急性肾功能不全的病例。资料包括对肾穿刺活检材料的电子显微镜观察，结果显示近端肾小管上皮细胞中存在电子致密物（细胞分隔小体），此前仅在动物实验和人体尸检研究中描述过这种情况。该例庆大霉素所致肾衰竭的临床过程及良好转归为对这种氨基糖苷类抗生素的动力学和毒性倾向进行一些有趣的思考提供了机会。
