接受抗高血压治疗患者中拉贝洛尔的平均稳态血浆浓度。
Mean steady-state plasma concentrations of labetalol in patients undergoing antihypertensive therapy.
作者信息
Sanders G L, Routledge P A, Ward A, Davies D M, Rawlins M D
出版信息
Br J Clin Pharmacol. 1979;8(Suppl 2):153S-155S.
1 Mean steady-state plasma concentrations of labetalol (labetalol Css) in 17 hypertensive patients undergoing chronic treatment with this drug, have been examined in relation to dose, fall in BP, and beta-blockade. 2 A significant relationship (rs = 0.81, P less than 0.001) was observed between labetalol Css and daily dose. 3 No correlation was found between labetalol Css and antihypertensive response. 4 In thirteen patients, there seemed to be significant relationship between labetalol Css and beta-blockade (rs = 0.72, P less than 0.005). In three patients, the degree of beta-blockade was disproportionate to the drug concentration.
1 对17例接受拉贝洛尔长期治疗的高血压患者，研究了其拉贝洛尔的平均稳态血浆浓度（拉贝洛尔Css）与剂量、血压下降及β受体阻滞之间的关系。2 观察到拉贝洛尔Css与日剂量之间存在显著相关性（rs = 0.81，P<0.001）。3 未发现拉贝洛尔Css与降压反应之间存在相关性。4 在13例患者中，拉贝洛尔Css与β受体阻滞之间似乎存在显著关系（rs = 0.72，P<0.005）。在3例患者中，β受体阻滞程度与药物浓度不成比例。
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