Cope D H
Br J Clin Pharmacol. 1979;8(Suppl 2):223S-227S.
The drugs that are available to attain controlled hypotension during anaesthesia are not entirely satisfactory. Problems in controlling hypotension are encountered in the young, the anxious, patients with a tachycardia, and in those for whom halothane is contra-indicated. Labetalol has been investigated as an adjunct to controlled hypotension in 150 major surgical procedures. Anaesthetic technique, labetalol dosage and results are discussed. Labetalol in patients under halothane anaesthesia resulted in a rapid attainment of hypotension which was easily controlled, and quickly and permanently reversed by the intravenous administration of atropine sulphate. It was especially useful in patients in whom problems with other techniques can be anticipated. Controlled hypotension with labetalol was also used in patients with ischaemic heart disease with good cardiovascular control and without any untoward effects.
麻醉期间用于实现控制性低血压的药物并不完全令人满意。在年轻人、焦虑患者、心动过速患者以及禁忌使用氟烷的患者中，控制低血压时会遇到问题。拉贝洛尔已在150例大手术中作为控制性低血压的辅助药物进行了研究。讨论了麻醉技术、拉贝洛尔剂量及结果。在氟烷麻醉的患者中，拉贝洛尔可迅速导致低血压，且易于控制，通过静脉注射硫酸阿托品可快速且永久性地逆转。在预计使用其他技术会出现问题的患者中，它特别有用。拉贝洛尔控制性低血压也用于缺血性心脏病患者，心血管控制良好且无任何不良影响。
