Tapanainen J, Penttinen J, Huhtaniemi I
Biol Neonate. 1979;36(5-6):290-7. doi: 10.1159/000241242.
The high progesterone (P) level of pregnancy was mimicked in neonatal male rats. The rats received 10, 30 or 100 microgram/g body weight of P in daily subcutaneous injections for 1, 2 or 3 weeks. It was expected that the treatment would yield developmental and functional changes similar to those possibly occurring under the influene of P in utero. P did not significantly affect the body weights of the animals, but significantly decreased the weights of the adrenals. Testicular weight was increased in the P-treated rats, and the number of Leydig cells was higher than in the controls. Peripheral serum testosterone and corticosterone, and testicular testosterone levels were only slightly decreased by the treatment. The changes observed in these neonatal animals suggest a regulatory function for P in the development of the fetal adrenal gland and testis.
在新生雄性大鼠中模拟了孕期高孕酮（P）水平。这些大鼠每天皮下注射10、30或100微克/克体重的P，持续1、2或3周。预期该处理会产生与子宫内受P影响时可能发生的发育和功能变化相似的情况。P对动物体重没有显著影响，但显著降低了肾上腺的重量。经P处理的大鼠睾丸重量增加，且莱迪希细胞数量高于对照组。该处理仅使外周血清睾酮和皮质酮以及睾丸睾酮水平略有下降。在这些新生动物中观察到的变化表明P在胎儿肾上腺和睾丸发育中具有调节功能。
